Possible Interaction: Ethanol and Hydrogen Peroxide

“In addition, administration of ethanol (0.02 ml/g) led to the elevation of oxidative stress indicators [ hydrogen peroxide (H₂O₂) and malondialdehyde (MDA)].”

“ Hydrogen peroxide is further reduced to water by catalase in the presence of ethanol.”

“In this study, we investigated the possible protective effects of ethanol and aqueous extracts of rosemary on human lymphocyte DNA damage induced by H2O2.”

“However, the co-exposure of cells to H2O2 and the crude extract or ethanol precipitate of U. rigida induced fewer morphological cytotoxic effects, a significant increase in cell viability, and a significant decrease in LDH release.”

“ Ethanol (50 mM) induced H2O2 production in platelets by Ca2+-dependent and independent mechanisms.”

“In conclusion we provide considerable evidence that ethanol alters Ca2+ entry and reduces thrombin-induced aggregation as a result of the generation of H2O2 and the oxidation of sulphydryl groups in human platelets.”

“ Chronic ethanol consumption significantly increases hydrogen peroxide and decreases mitochondrial glutathione (GSH) in cells overexpressing CYP2E1.”

“Combinations other than AE + H2O2 showed possible interactions, which lead to reduction in their potency.”

“The results obtained showed that ethanol , glycerol, the catechin-caffeic acid mixture, the mixture of all components and the stripped white wine significantly reduced the DNA-damaging effects of hydrogen peroxide and gamma-radiation (P = 0.043-0.001, ANOVA).”

“These two treatments as well as ethanol produced the strongest protective effects against DNA damage by hydrogen peroxide (24, 25 and 18%, respectively).”

“as a consequence of ethanol drinking and resultant endogenous synthesis of 8,9A, and 9B would, based on these in vitro chemical studies, be expected to generate elevated fluxes of H2O2 and HO.”

“Addition of 0.4% ethanol had no effect on superoxide concentration (102.2%), but tended to decrease hydrogen peroxide (83.5%) and 8OHdG (84.3%).”