supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Ethanol
drug:
Hydralazine
Research Papers that Mention the Interaction
“When ethanol was added to the perfusate to monitor blood flow, the escape of alcohol from the dialysate was accelerated by 30% with hydralazine or nitroprusside (P < 0.01) and 30% retarded (P < 0.05) by clonidine (10(-10) mol/liter).”
Role of vascular alpha-2 adrenoceptors in regulating lipid mobilization from human adipose tissue.“Our previous studies showed that chronic ethanol feeding attenuates centrally (clonidine) evoked and potentiates peripherally ( hydralazine ) evoked hypotension in female rats.”
Bradykinin B2 Receptor–Dependent Enhancement of Enalapril-Evoked Hypotension in Ethanol-Fed Female Rats“In contrast to its antagonistic effect on clonidine hypotension, ethanol significantly potentiated the hypotensive effect of hydralazine.”
“Because we previously observed that 1-hydrazinophthalazine (hydralazine) strongly diminishes the toxicity of the acrolein precursor allyl alcohol , we explored the possibility that hydralazine targets reactive acrolein adducts in proteins.”
“ Ethanol given after hydralazine produced a short-lived pressor effect (<10 min vs. 60 min in case of clonidine) in spite of a sustained increase in TPR.”
“ Ethanol given after hydralazine produced a short-lived pressor effect (<5 minutes versus 40 minutes in the case of clonidine) and counteracted the sympathetically mediated increases in cardiac output, stroke volume, and heart rate.”
“Pretreatment of the animals with hydralazine (1-10 mg kg-1 orally) significantly enhanced ethanol- , reserpine- and cold-stress-induced ulcers.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback