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Last Updated: 2 years ago

Possible Interaction: Ethanol and Hydralazine

supplement:

Ethanol

Research Papers that Mention the Interaction

When ethanol was added to the perfusate to monitor blood flow, the escape of alcohol from the dialysate was accelerated by 30% with hydralazine or nitroprusside (P < 0.01) and 30% retarded (P < 0.05) by clonidine (10(-10) mol/liter).
The Journal of clinical investigation  •  1993  |  View Paper
Our previous studies showed that chronic ethanol feeding attenuates centrally (clonidine) evoked and potentiates peripherally ( hydralazine ) evoked hypotension in female rats.
Journal of cardiovascular pharmacology  •  2011  |  View Paper
In contrast to its antagonistic effect on clonidine hypotension, ethanol significantly potentiated the hypotensive effect of hydralazine.
Vascular pharmacology  •  2004  |  View Paper
Because we previously observed that 1-hydrazinophthalazine (hydralazine) strongly diminishes the toxicity of the acrolein precursor allyl alcohol , we explored the possibility that hydralazine targets reactive acrolein adducts in proteins.
Molecular pharmacology  •  2004  |  View Paper
Ethanol given after hydralazine produced a short-lived pressor effect (<10 min vs. 60 min in case of clonidine) in spite of a sustained increase in TPR.
Journal of cardiovascular pharmacology  •  1999  |  View Paper
Ethanol given after hydralazine produced a short-lived pressor effect (<5 minutes versus 40 minutes in the case of clonidine) and counteracted the sympathetically mediated increases in cardiac output, stroke volume, and heart rate.
Hypertension  •  1997  |  View Paper
Pretreatment of the animals with hydralazine (1-10 mg kg-1 orally) significantly enhanced ethanol- , reserpine- and cold-stress-induced ulcers.
Pharmacological research  •  1994  |  View Paper