Possible Interaction: Ethanol and Histidine

“was able to partially reverse the attenuation of ethanol induced anxiolysis by l-histidine (1000mg/kg, i.p.).”

“Organic zinc salts such as zinc aspartate, zinc orotate, zinc histidine and zinc acetate protected mice against the lethality of an acute intraperitoneal challenge with ethanol.”

“With C. fasciculata topoisomerase, GSH, DTT and NAC protected 100%, cysteine, histidine and mannitol protected 28%, 34% and 48%, respectively, whereas ethanol was ineffective.”

“ Histidine was also decreased in placenta by ethanol (138.1 +/- 6.6 vs. 189.1 +/- 11.8 nmole/g, p = 0.0014).(ABSTRACT TRUNCATED AT 250 WORDS)”

“In hepatocytes from starved rats, asparagine, serine, ornithine, hydroxyproline, histidine , cysteine, alanine, glycine, glutamate, glutamine, aspartate and arginine significantly increase ethanol consumption.”

“In hepatocytes from fasted rats, alanine, arginine, asparagine, aspartate, citrulline, cysteine, glutamate, glutamine, glycine, histidine , hydroxyproline, ornithine and serine increase significantly ethanol consumption.”

“Carbon-centered radicals of alcohols commonly used as hydroxyl radical scavengers (MeOH, EtOH , i-PrOH and t-BuOH) add reversibly to histidine with equilibrium constants up to 3 × 10(3) M(-1) and rate constants on the order of 10(9) M(-1) s(-1).”

“In support of this hypothesis, supplementation of isoleucine, tryptophan, and histidine to the culture medium increased the specific growth rate under ethanol stress.”

“Wrong location of alcohol and oleic acid severely hinders reaction because it hinders the H-transfer to histidine , a key step in the reaction mechanism.”

“However, the ethanol extracts had a rather higher inhibitory action upon histidine , lysine, and ornithine decarboxylases.”