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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Ethanol
drug:
Hexobarbital
Research Papers that Mention the Interaction
“ Ethanol competitively inhibited the binding of hexobarbital to liver microsomes, and increased the low spin signal of cytochrome P-450 in the electron spin resonance spectra.”
Inhibition of cytochrome P-450-dependent mixed function oxidation by ethanol“If hexobarbital , a substrate of mixed function oxygenase as well as an "uncoupler", is given to guinea pigs together with ethanol , changes in the elimination of ethanol occur.”
“The results also show additional interactions of hexobarbital as well as of ethylmorphine with ethanol elimination.”
“ Ethanol decreased the plasma and total body half-lives of hexobarbital in both dietary models, but they were decreased significantly more with the high-fat diet.”
“ Ethanol , administered chronically in nutritionally adequate liquid diets, increases tolerance to hexobarbital by increasing drug disposition and by decreasing central nervous system sensitivity.”
“Prolonged alcohol or DHET consumption was found to prolong hexobarbital sleeping time and increase oxygen consumption.”
“But stress alone or with ethanol reduced the HB sleep time, results which suggest that sleep time is not a reliable index of metabolism in stressed rats.”
“ Ethanol alone or in combination with stress also increased HB sleep time.”
“This study shows that the effects of acute stress and alcohol on HB metabolism are additive.”
“A dose-response relationship was found for ethanol inhibition of Hb metabolism.”
“Oral administration of 3 g/kg of ethanol (15% w/v) inhibited Hb hydroxylase activity 45–50 per cent.”
“Administration of one dose of ethanol significantly increased the rates of elimination of zoxazolamine and of hexobarbital from the circulation 17 hr later, but the rate of warfarin elimination was unchanged.”
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