Possible Interaction: Ethanol and Heparin

“Heparin was lost in contact with blood but the alcohol treatment delayed heparin desorption significantly.”

“The lipase activity affected by ethanol was inhibited in vitro by protamine sulfate, 1 M NaCl and diisopropyl fluorophosphate and enhanced by heparin.”

“On the other hand, although ethanol solutions under 70% form less precipitate with heparin , such concentrations are also less effective at bacterial colony inhibition than solutions of either 70% ethanol or 35% isopropanol-35% ethanol (p<0.05).”

“We hypothesized that precipitate forms when ethanol mixes with heparin at the concentrations relevant for vascular access devices, but that the use of a combination of two alcohols, ethanol and isopropanol, would diminish heparin-related precipitation, while retaining anti-bacterial and anti-fungal effects.”

“ Ethanol at 3 per thousand (the maximum-effect concentration) inhibited the CaCl2 induced contraction … g. Incubation of aorta with ruthenium red (10(-5) mol/L) or heparin (50 mg/L) decreased the vasodilating effect of ethanol (3.0 … on rat thoracic aorta, which is concerned with the resting tension.”