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Last Updated: 2 years ago

Possible Interaction: Ethanol and Gossypol

supplement:

Ethanol

supplement:

Gossypol

Research Papers that Mention the Interaction

Ethanol extracts from glanded and glandless cottonseed kernels and gossypol significantly decreased breast cancer cell mitochondrial activity.
Scientific Reports  •  2018  |  View Paper
As gossypol and ethanol are both associated with reduced reproductive capacity, this unexpected but interesting finding lends support to the hypothesis that either a normal dietary protein or ethanol consumption may modify the action of gossypol on body tissues, including the testis.
Andrologia  •  1997  |  View Paper
Serum creatine phosphokinase activity was depressed in all gossypol‐treated rats and gossypol caused greater decreases than ethanol in those animals that were fed the normal diet.
These findings indicated that either adequate levels of protein in the diet and/or ethanol consumption have the effect of reducing gossypol toxicity, probably by reducing the amount of gossypol available for tissue exposure through enhanced metabolism and/or clearance from the body.
Journal of applied toxicology : JAT  •  1996  |  View Paper
As the livers of gossypol-treated rats were significantly heavier than in these animals, it seems possible that ethanol consumption enhances the ability of the liver to metabolize gossypol , thereby reducing its accumulation and consequently its toxicity.
Journal of comparative pathology  •  1994  |  View Paper
The behavioral study suggests adverse metabolic interaction between gossypol and alcohol which may underlie the rat aversion to voluntary ethanol drinking.
Toxicology letters  •  1991  |  View Paper
A toxic metabolic interaction between ethanol and gossypol has been indicated which suggests the contraindication of alcoholic beverages during gossypol use.
General pharmacology  •  1991  |  View Paper