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Last Updated: 3 years ago
supplement:
Ethanol
Research Papers that Mention the Interaction
“ Ethanol administration enhanced the T response to GnRH (p less than 0.001 vs placebo).”
“In contrast, following ethanol intake, T levels were significantly elevated within 30 min after GnRH administration, at which time the mean increment over baseline was 187 +/- 42 ng/dl.”
Acute ethanol administration enhances plasma testosterone levels following gonadotropin stimulation in men“As chronic alcohol ALC ) exposure acts at the hypothalamic level to suppress LHRH secretion and delay puberty, we assessed its ability to differentially affect the expression of key puberty-related proteins.”
“As we have shown that alcohol (ALC) diminishes prepubertal LHRH secretion and delays puberty, we first assessed the effects of short-term ALC administration on the basal expression of a specific gene family involved in glial-neuronal communications.”
“ Alcohol is one such substance known to diminish LHRH secretion and delay the initiation of puberty.”
“ Ethanol alone decreased the specific binding of [(125)I]-labelled GnRH isoform (IC(50), 7.9 +/- 0.8 mg/ml; n = 6) or agonist tracers (IC(50), 10.0 +/- 1.4 mg/ml; n = 6) to human placental membranes in a dose-dependent manner.”
“Thus, ethanol can perturb the human placental GnRH/GnRH-receptor system in vitro in two distinct ways: by inhibition of GnRH binding to receptor, and by dissociation of complexed endogenous GnRH-like factor(s) from a GnRH-binding protein.”
“Food restriction and underweight (anorexia nervosa), obesity, smoking, and alcohol all have negative effects on the GnRH pulse generator and gonadal function.”
“BACKGROUND Alcohol ALC ) causes suppressed secretion of prepubertal luteinizing hormone-releasing hormone (LHRH).”
Regulation of Kisspeptin Synthesis and Release in the Preoptic/Anterior Hypothalamic Region of Prepubertal Female Rats: Actions of IGF‐1 and Alcohol“COX2 synthesis, as well as PGE2 and LHRH release were suppressed by ALC exposure, but Mn supplementation caused an increase in COX2 synthesis and subsequent PGE2 and LHRH release in the presence of ALC.”
“BACKGROUND Alcohol ALC ) diminishes gonadotropin-releasing hormone ( GnRH ) secretion and delays puberty.”
“Finally, TGFβ1 was shown to induce release of the GnRH peptide in vitro, an action that was blocked by ALC.”
“Since alcohol (ALC) blocks IGF-1 induced LHRH release acutely, we assessed whether this drug could affect IGF-1 stimulated prepubertal KiSS-1 gene expression following a binge type of exposure.”
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