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Last Updated: 3 years ago

Possible Interaction: Ethanol and Gonadotropin-Releasing Hormone

Research Papers that Mention the Interaction

Ethanol administration enhanced the T response to GnRH (p less than 0.001 vs placebo).
In contrast, following ethanol intake, T levels were significantly elevated within 30 min after GnRH administration, at which time the mean increment over baseline was 187 +/- 42 ng/dl.
Psychoneuroendocrinology  •  1987  |  View Paper
As chronic alcohol ALC ) exposure acts at the hypothalamic level to suppress LHRH secretion and delay puberty, we assessed its ability to differentially affect the expression of key puberty-related proteins.
Alcoholism, clinical and experimental research  •  2015  |  View Paper
As we have shown that alcohol (ALC) diminishes prepubertal LHRH secretion and delays puberty, we first assessed the effects of short-term ALC administration on the basal expression of a specific gene family involved in glial-neuronal communications.
Alcoholism, clinical and experimental research  •  2011  |  View Paper
Alcohol is one such substance known to diminish LHRH secretion and delay the initiation of puberty.
Alcohol  •  2015  |  View Paper
Ethanol alone decreased the specific binding of [(125)I]-labelled GnRH isoform (IC(50), 7.9 +/- 0.8 mg/ml; n = 6) or agonist tracers (IC(50), 10.0 +/- 1.4 mg/ml; n = 6) to human placental membranes in a dose-dependent manner.
Thus, ethanol can perturb the human placental GnRH/GnRH-receptor system in vitro in two distinct ways: by inhibition of GnRH binding to receptor, and by dissociation of complexed endogenous GnRH-like factor(s) from a GnRH-binding protein.
Molecular human reproduction  •  1999  |  View Paper
Food restriction and underweight (anorexia nervosa), obesity, smoking, and alcohol all have negative effects on the GnRH pulse generator and gonadal function.
Environmental health perspectives  •  1993  |  View Paper
BACKGROUND Alcohol ALC ) causes suppressed secretion of prepubertal luteinizing hormone-releasing hormone (LHRH).
Alcoholism, clinical and experimental research  •  2018  |  View Paper
COX2 synthesis, as well as PGE2 and LHRH release were suppressed by ALC exposure, but Mn supplementation caused an increase in COX2 synthesis and subsequent PGE2 and LHRH release in the presence of ALC.
Life sciences  •  2016  |  View Paper
BACKGROUND Alcohol ALC ) diminishes gonadotropin-releasing hormone ( GnRH ) secretion and delays puberty.
Finally, TGFβ1 was shown to induce release of the GnRH peptide in vitro, an action that was blocked by ALC.
Alcoholism, clinical and experimental research  •  2014  |  View Paper
Since alcohol (ALC) blocks IGF-1 induced LHRH release acutely, we assessed whether this drug could affect IGF-1 stimulated prepubertal KiSS-1 gene expression following a binge type of exposure.
Neuroscience  •  2010  |  View Paper
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