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Possible Interaction: Ethanol and Glutathione





Research Papers that Mention the Interaction

Ethanol ingestion brought about a significant increase in xanthine oxidase and malonyldialdehyde together with a decreased glutathione concentration.
Digestion  •  1999  |  View Paper
The relationship between glutathione, GGTP and glucaric acid is discussed, suggesting the possible role of GSH against the oxidative damage of alcohol.
La Clinica terapeutica  •  1992  |  View Paper
What remains unknown is whether the negative impact on GSH levels can be modified as a result of limiting alcohol and tobacco use.
Journal of affective disorders  •  2015  |  View Paper
Bioinformatic pathway analysis of hepatic carbonylated proteins revealed a propensity of long term EtOH consumption to increase post-translational carbonylation of proteins involved in glutathione homeostatic , glycolytic and cytoskeletal pathways.
Free radical biology & medicine  •  2015  |  View Paper
Interestingly, the level of the antioxidant GSH was found to be 3-fold upregulated in VL-17A cells treated with ethanol , which may be a metabolic adaptation to the persistent and overwhelming oxidative stress.
Toxicology in vitro : an international journal published in association with BIBRA  •  2011  |  View Paper
Although the antioxidant glutathione GSH ) and its oxidized component glutathione disulfide (GSSG) have been demonstrated to be significantly altered in the adult alcoholic , the effects of maternal alcohol use during pregnancy on oxidant stress in the postpartum female remain under investigation.
alcohol use during pregnancy significantly decreased plasma GSH (p < 0.05), while alcohol at >3 drinks/occasion or >5 drinks/occasion significantly decreased plasma GSH concentration (p < 0.05), increased the percent of oxidized GSSG (p < 0.05), and substantially oxidized the plasma GSH redox potential (p < 0.05).
Alcoholism, clinical and experimental research  •  2010  |  View Paper
Ethanol … GSH in hHeps, causing apoptosis with a release of approximately 40% total LDH after 72 h. Similar to incubation with hemin preincubation and co-incubation … a dose-dependent manner, by initiating nuclear translocation of Nrf2 which in turn induces HO-1 under the control of p38 and ERK.
Digestive diseases  •  2010  |  View Paper
Many … ethanol induces a state of "oxidative stress", including redox-state changes, acetaldehyde production, damage to the mitochondria, membrane injury, apoptosis, ethanol-induced … production, increased endotoxin levels and activation of Kupffer cells, mobilization of iron, changes in the antioxidant defense, particularly mitochondrial glutathione ( GSH ), one electron oxidation … of CYP2E1.
Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva  •  2008  |  View Paper
On the contrary, the levels of GSH were reduced after the treatment of alcohol , but there was a higher level of GSH in the group pretreated with WPC.
Journal of agricultural and food chemistry  •  2008  |  View Paper
Additionally, intracellular GSH levels were significantly reduced after ethanol or AA treatment.
International journal of hygiene and environmental health  •  2008  |  View Paper
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