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Last Updated: 3 years ago

Possible Interaction: Ethanol and Glutathione Disulfide

Research Papers that Mention the Interaction

In the study, we have examined the effect of chronic ethanol exposure on hepatic glutatione levels and found that ethanol exposure resulted in elevations of hepatic reduced and oxidized glutathione.
Research communications in chemical pathology and pharmacology  •  1979  |  View Paper
Any alcohol use during pregnancy significantly … plasma GSH (p < 0.05), while alcohol at >3 drinks/occasion or >5 drinks/occasion significantly decreased plasma GSH concentration (p < 0.05), increased the percent of oxidized GSSG (p < 0.05), and substantially oxidized the plasma GSH redox potential (p < 0.05).
Alcoholism, clinical and experimental research  •  2010  |  View Paper
Thus, a greater percentage was in the oxidized GSSG form when subjects abused alcohol (35.3% [11.8, 58.1] vs. 5.2 [3.6, 6.1], p<0.001).
Respiratory medicine  •  2008  |  View Paper
The metabolism of ethanol can result in depletion of reduced glutathione (GSH) via adduct formation and oxidation to GSSG.
Journal of hepatology  •  1986  |  View Paper
In addition, EtOH induced an accumulation of GSSG and consequent reduction of GSH:GSSG ratio, indicating the involvement of oxidative mechanisms in the EtOH-induced effects.
Chemico-biological interactions  •  2020  |  View Paper
RESULTS Et H ad ministration significantly increased hepatic oxidative stress, evidenced as decreased liver total glutathione and reduced glu tathione/glutathione disulfide ra tio.
Alcoholism, clinical and experimental research  •  2014  |  View Paper
EtOH increased 8-hydroxy-2'-deoxyguanosine and decreased reduced and oxidized glutathione.
Journal of agricultural and food chemistry  •  2009  |  View Paper
Chronic ethanol feeding alone decreased the ratio of reduced/oxidized glutathione and increased 8-hydroxydeoxy-guanosine and tumor necrosis factor (TNF)-α levels in the gingiva.
Journal of dental research  •  2008  |  View Paper
Ethanol significantly decreased the plasma NO levels, reduced to oxidized glutathione ratio (GSH/GSSG) and antioxidant enzymes-superoxide dismutase (CuZn-SOD, and Mn-SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) activities while plasma NADPH oxidase activity and malondialdehyde (MDA) levels were significantly elevated compared to control.
Molecular and Cellular Biochemistry  •  2006  |  View Paper
In addition, ethanol consumption caused age-dependent decreases in the levels of GSH, selenium, vitamins, E, A and C, and beta-carotene and increases in the levels of oxidized glutathione (GSSG).
Alcohol  •  2005  |  View Paper
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