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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“The inhibitory effect of 60 min ethanol at 5 to 15 mM on the POMC PT levels was attenuated by 50 μM L-glutamate.”
Modulation of proopiomelanocortin gene expression by ethanol in mouse anterior pituitary corticotrope tumor cell AtT20“After acute in vivo ethanol treatment, in vitro ethanol (48 mM) exposure also decreased stimulated GLU release in the hippocampus of the immature and mature fetus and decreased basal GLU release only in the immature fetus.”
“Overall, the data indicate that ethanol depresses GLU release in the hippocampus of the guinea pig and that the fetal hippocampus is more susceptible to these depressant effects.”
Effects of acute ethanol exposure on glutamate release in the hippocampus of the fetal and adult guinea pig.“These data indicate the L-glutamate , an excitatory amino acid neurotransmitter, can enhance the central depressant action of ethanol.”
“ Ethanol (65 mM) inhibition of L-glutamate (60 microM) contractions increased from 30% after a 2 min preincubation to a maximum of 60% following 10 min.”
“Preincubation with ethanol (30-100 mM) for 2 min inhibited contractions to L-glutamate by up to 50% and caused additive inhibition with 100 microM Mg2+.”
“ L-glutamate and pyruvate, when added to the Krebs-Ringer incubation medium, reversed the inhibition by ethanol.”
“Moreover, Glu , but not Asp, effectively reversed the acute inhibition of steroidogenesis by ethanol.”
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