Possible Interaction: Ethanol and Genistein

“ Genistein stimulated PC biosynthesis by 30 per cent as well as partially preventing /reversing the ETOH action, while tyrphostin 25 produced a synergistic inhibition.”

“Unlike protein kinase inhibitors, pretreatment with tyrosine kinase inhibitors (erbstatin, genistein and tyrphostin 25) resulted in differential effects on PC biosynthesis and on the inhibitory action of ETOH.”

“ Genistein … alcohol concentration , inhibited the activities of alanine and aspartate aminotransferases and decreased levels of inflammatory mediators, including interleukin 6, tumor necrosis factor-α and myeloperoxidase, … collagen deposition and reduced pathological tissue damage as determined by hepatic fibrosis biomarkers, such as total hyaluronic acid, laminin, and type III collagen.”

“The amounts of two primary soy isoflavones, genistein and daidzein, in the extracts also increased with increasing amount of EtOH.”

“ Genistein (5 micromol/L) decreased ethanol (P = 0.045) and tended to decrease acetaldehyde (P = 0.10) concentrations in the culture filtrate.”

“ Ethanol induces transient and sustained increases in [Ca2+]i in primary single smooth muscle cells from canine basilar arteries, which are markedly attenuated in the presence of genistein , an SH2 domain inhibitor peptide, SB-203580, U0126, and PD-98059.”

“Like epidermal growth factor-urogastrone (EGF), the contractile actions of ethanol in the LM and CM preparations required extracellular calcium and were blocked by the tyrosine kinase inhibitors, genistein and tyrphostin-47 (AG213).”