Possible Interaction: Ethanol and Gaboxadol

“However, age-dependent differences were revealed following the administration of THIP , with adolescents exhibiting greater sensitivity to its suppressant effects, especially during the first 30 minutes of binge EtOH access.”

“Together, these findings suggest that THIP may have effectively prevented the decrease in ethanol intake on day 7 induced by the microinjection process, perhaps supporting a suggested role for the ILC in adaptive learning processes and behavioral flexibility.”

“ THIP dose-dependently decreased ethanol intake in both paradigms, altering both the consummatory and appetitive processes of operant self-administration as well as shifting the drinking patterns in both procedures.”

“Baclofen dose-dependently increased binge-like ethanol intake, while both muscimol and THIP reduced ethanol intake.”

“The present study … the ability of THIP (2, 4, or 8 mg/kg) and baclofen (5.0, 6.25, or 7.5 mg/kg), GABAA and GABAB agonists, respectively, to prevent development of sensitization to the locomotor stimulant effects of ethanol (2 g/kg) in DBA/2 J mice.”

“More specifically, the GABAA agonist THIP increased the intake of ethanol as compared to baseline measures, while the GABA antagonist picrotoxin decreased ethanol intake.”

“Similarly, the administration of THIP increased ethanol preference.”

“Subjects treated with THIP consumed significantly greater amounts of ethanol than did saline controls.”

“The qualitatively different patterns in the microstructure of consummatory behavior for ethanol and food following THIP treatment would suggest that differential mechanisms may mediate the food and ethanol effects observed in the present study.”

“This conclusion was further supported by the finding that another GABAA agonist, THIP (500 ng), also selectively increased ethanol intake in this paradigm, injection of biculline (60 ng) into the dorsal raphe reduced ethanol intake, but also appeared to reduce water intake.”