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Last Updated: 3 years ago

Possible Interaction: Ethanol and Gabapentin



Research Papers that Mention the Interaction

Gabapentin was associated with significantly greater reductions than placebo on several measures of subjective craving for alcohol as well as for affectively evoked craving.
Addiction biology  •  2009  |  View Paper
Although not all sources reported the specifics on other substances taken by these patients, it is clear that the abuse of illicit and prescription drugs, as well as alcohol , is a strong risk factor for the abuse of gabapentin as well.
Their concomitant use of alcohol or illicit substances along with inappropriate use of gabapentin was documented in many of the case reports cited and was reiterated in our review.
The Annals of pharmacotherapy  •  2016  |  View Paper
Benzodiazepines, clomethiazole, tiagabine, vigabatrin, pregabalin, gabapentin , acamprosate, naltrexone, GHB, topiramate, ondansetron and baclofen at low dose (≤1 mg/kg, the dose range used in randomized trials in humans: 30 and 60 mg/day) have all been shown to at best reduce motivation to consume alcohol in rats.
Journal of psychopharmacology  •  2012  |  View Paper
2 Given this effect, it is perhaps not surprising that several studies have shown that gabapentin decreases alcohol withdrawal symptoms and may decrease cravings for alcohol in alcohol-dependent individuals.
The Journal of clinical psychiatry  •  2007  |  View Paper
Collectively, these findings show that gabapentin reverses behavioral measures of ethanol dependence and, in turn, dependence reverses the effects of gabapentin on CeA neurons, and suggest that gabapentin represents a potential medication for treatment of alcoholism.
Systemic gabapentin reduced ethanol intake in dependent, but not in nondependent, rats and reversed the anxiogenic-like effects of ethanol abstinence using an acute dependence model.
The Journal of Neuroscience  •  2008  |  View Paper
Gabapentin administered both in a single dose and for 7 days markedly enhanced the effect of ethanol on EEG recordings in rabbits.
Repeated doses of gabapentin decrease the sensitivity of the hippocampus to the effect of ethanol.
The mechanism of gabapentin effect suggests that it may alleviate the rewarding effect of ethanol , which may be used in the treatment of addiction.
Basic & clinical pharmacology & toxicology  •  2006  |  View Paper
The results demonstrated that gabapentin has a selective action in decreasing both convulsive and anxiety-related aspects of withdrawal behaviour after chronic ethanol treatment.
Neuropharmacology  •  1997  |  View Paper
There was a significant positive correlation between the use of gabapentinoids and multiple drugs and alcohol and drug addiction, various withdrawal symptoms, the number of going to the infirmary, and the number of referral to the hospital (p<0.05).
Turkish journal of physical medicine and rehabilitation  •  2017  |  View Paper
Pregabalin and gabapentin have additional benefits to decrease alcohol cravings or time to relapse after a period of abstinence from alcohol.
Journal of pain research  •  2015  |  View Paper
Gabapentin (12.5-50 mg/kg) reduced the number and severity of gastric mucosal lesions induced by subcutaneous indomethacin (20 mg/kg) or intragastric 96% ethanol , but at doses of 50 and 100 mg/kg it increased gastric acid secretion.
Drug discoveries & therapeutics  •  2009  |  View Paper