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Last Updated: 3 years ago

Possible Interaction: Ethanol and Gaba Agonists



Research Papers that Mention the Interaction

The GABAB receptor agonist baclofen (3–30 ng) also suppressed ethanol intake, but the GABAB receptor antagonist saclofen (0.3–3 μg) failed to modify it.
Psychopharmacology  •  2012  |  View Paper
Adding to our previous results showing a reduction in ethanol induced activity by a GABA B agonist or a nonspecific opioid antagonist, the present experiments implicate both D1-like and D2-like dopamine receptors in ethanol-induced locomotor stimulation during early development.
Developmental psychobiology  •  2010  |  View Paper
We further show that ethanol significantly elevates basal presynaptic GABAB receptor tone, possibly via an increase in spontaneous GABA release, and that pretreatment with a subthreshold concentration of the GABAB receptor agonist baclofen blocks ethanol but not flunitrazepam or pentobarbital potentiation of GABAA IPSCs.
The Journal of Neuroscience  •  2004  |  View Paper
Moreover, they are affected by GABAergic mechanisms: the facilitatory effect of acute EtOH can be suppressed by pretreatment with a GABA receptor agonist whereas the inhibitory effects resulting from a GABA agonist can be occluded by ethanol exposure.
Front. Physiol.  •  2018  |  View Paper