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Last Updated: 3 years ago

Possible Interaction: Ethanol and Fomepizole



Research Papers that Mention the Interaction

In cultured human or mouse HSC, production of CTGF, α-SMA and/or collagen was increased by ethanol treatment, an effect mimicked by acetaldehyde and blocked by 4-methylpyrazole (4-MP) or N-acetylcysteine (NAC).
Journal of hepatology  •  2011  |  View Paper
Inhibition of EtOH metabolism by 4-methylpyrazole abolishes almost completely the Mg(2+) extrusion induced by the first dose of EtOH, and partially enlarges that elicited by the second dose of alcohol or the subsequent adrenergic stimulation.
Alcoholism, clinical and experimental research  •  2007  |  View Paper
4-Methylpyrazole , a specific inhibitor of the alcohol-metabolizing enzymes, abolished the effects of ethanol on hepcidin.
Journal of Biological Chemistry  •  2006  |  View Paper
This inhibitory effect on the proteasome was blocked when ethanol metabolism was blocked by 4-methyl pyrazole.
The international journal of biochemistry & cell biology  •  2006  |  View Paper
Whereas inhibition of ethanol oxidation by 4-methylpyrazole blocked the effect, the aldehyde dehydrogenase inhibitor cyanamide enhanced the effect of ethanol in the hepatoma cells, supporting the idea that the effect is likely mediated by acetaldehyde.
Alcohol  •  2004  |  View Paper
The ADH inhibitor 4-methyl pyrazole (4-MP) reduced ethanol oxidation in the skin and liver in a concentration dependent manner: activity was reduced to approximately 30-40% and approximately 2-10% of the control activity, in the skin and liver, respectively, using 1 mM 4-MP.
Toxicology  •  2003  |  View Paper
Although 4-methylpyrazole is a potent inhibitor of some of the liver alcohol dehydrogenases, it is not very effective against all of the human isoenzymes, and it is a competitive inhibitor against alcohol , which makes it less effective when the concentration of substrate alcohol is increased.
Advances in experimental medicine and biology  •  1999  |  View Paper
Generation of the factor is specific for hepatocytes and is blocked by inhibiting ethanol metabolism with 4-methylpyrazole.
Free radical biology & medicine  •  1989  |  View Paper
Chronic administration of ethanol and 4-methylpyrazole indicated that there is a mutual interaction in the metabolism of ethanol and 4-methylpyrazole , leading to a higher concentration of both ethanol and 4-methylpyrazole in the blood.
Combined treatment of ethanol and 4-methylpyrazole caused an increase of the microsomal drug-metabolizing activity.
Archives of biochemistry and biophysics  •  1980  |  View Paper
Several clinical chemical parameters showed no impairment of liver or kidney function, except for an enhancement of the microsomal drug-metabolizing activity after concurrent administration of 4-methylpyrazole and ethanol.
Proceedings of the National Academy of Sciences of the United States of America  •  1979  |  View Paper
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