Reduced SP1-mediated transcriptional activation decreases expression of intestinal folate transporters in response to ethanol exposure.

 transport as well as expression of folate transporters was observed on 

 treatment and the effects were reversible upon removal of ethanol.

Metabolic interactions of alcohol and folate.

 and, prospectively, in volunteers fed alcohol with low folate diets.

Regulation at multiple levels control the expression of folate transporters in liver cells in conditions of ethanol exposure and folate deficiency.

Folate deficiency resulted an increase, whereas

Serum unmetabolized folic acid: the straw that broke dihydrofolate reductase's back?

 (6) or inhibits apical renal reabsorption of folate (7).

Folic Acid Transport to the Human Fetus Is Decreased in Pregnancies with Chronic Alcohol Exposure

Animal and in vitro studies have suggested that

 across the placenta by decreasing expression of transport proteins.

Folate and related micronutrients, folate-metabolising genes and risk of ovarian cancer

Conclusions:Our data provide little evidence to support a protective role for folate in ovarian carcinogenesis but suggest further evaluation of the joint effects of

Diet and cancer: one view at the start of the millennium.

 appear strongest among persons who regularly consume 

, which itself is associated with risk of these cancers.

Diet and cancer.

[Megalocytic anemia of alcoholics and folic acid (author's transl)].

 has a toxic effect on the marrow and inhibits the 

Ethanol-induced inhibition of human intestinal enzyme activities: reversal by folic acid.

The effect of ethanol and folic acid on intestinal enzyme activities demonstrates how

 may interact by affecting mutually susceptible enzymes.

Decreased jejunal uptake of labeled folic acid ( 3 H-PGA) in alcoholic patients: roles of alcohol and nutrition.

This study confirms that the absorption of

Drugs, toxins and dietary amino acids affecting vitamin B12 or folic acid absorption or utilization.

Abstract Absorption, transport or utilization of vitamin B 12 or

 is reduced by a growing number of drugs, as well as by 

 and B 12 metabolism by a variety of mechanisms, including production of intestinal malabsorption and interference with folate metabolism, and possibly may act as a hematologic toxin by mechanisms other than disturbance of vitamin B 12 or folic acid metabolism.

Folic acid prevents functional and structural heart defects induced by prenatal ethanol exposure.

Embryos exposed to ethanol showed significantly increased regurgitant blood flow compared to controls, while embryos given

 had significantly reduced regurgitant blood flow but did not return to control levels.

 exposure led to significantly smaller, abnormal endocardial cushions and the addition of 

 improved their size, but they remained smaller than controls.

Folic acid supplement rescues ethanol-induced developmental defects in the zebrafish embryos.

Moreover, it is very important to determine the optimal time for

 supplementation when it can most effectively antagonize the teratogenic effects of 

 at 6-12 h post-fertilization (hpf), which is at the gastrula period (5.25-10 hpf), can obviously prevent the teratogenicity of 

Protective effects of quercetin, polydatin, and folic acid and their mixtures in a zebrafish (Danio rerio) fetal alcohol spectrum disorder model.

 and QUE protected against these ethanol-induced defects.

In conclusion, this study presents new evidence that QUE, POL,

 and their mixtures partially protected epiboly, teratogenic, and behavioral defects induced by 

In vivo assay of the ethanol-induced embryonic hair cell loss and the protective role of the retinoic and folic acid in zebrafish larvae (Danio rerio).

 (0.1 mM) acid with the same concentrations of 

 resulted in significant increases in the remaining hair cells, compared to the ethanol-only treatment group, for every ethanol concentration.

The effects of ethanol upon hydric balance and arterial pressure in rats: folic acid as a possible hypotensor.

take improves the hypertension provoked by alc

 increasing the aldosterone clearance, drastically reducing the serum levels of this hormone and thus its hypertensor effect.

Effects of folic acid and amino acids supplementation on zinc intestinal absorption in the progeny of ethanol-treated rats

These results indicate that supplementation of

 during gestation and lactation increase serum and milk zinc levels, although the zinc ingestion is lower.

Folic acid and selenite during reproduction, gestation and lactation protect against ethanol changed Se bioavailability.

 and selenium decrease in dams exposed to 

 during gestation and lactation, affecting their antioxidant status, their reproductive function and consequently the health of their progeny.

Selenium or selenium plus folic acid intake improves the detrimental effects of ethanol on pups' selenium balance.

 and selenium, two nutrients with antioxidant properties, decrease in dams exposed to 

Beneficial role of dietary folic acid on cholesterol and bile acid metabolism in ethanol-fed rats.

In previous articles, we demonstrated the anti-oxidant capacity of

, which may be useful in the prevention of damage provoked by 

Developmental toxicity of ethanol in chick heart in ovo and in micromass culture can be prevented by addition of vitamin C and folic acid.

Data obtained in this study suggest that supplementation with vitamin C or

 during pregnancy may prevent defects in heart development brought about by 

Dietary selenium plus folic acid as an antioxidant therapy for ethanol-exposed pups.

 and selenium are decreased in dams exposed to 

 during gestation and lactation, affecting their metabolism, antioxidant balance, and the future health of their progeny.

Effect of folic acid on prenatal alcohol-induced modification of brain proteome in mice

Results of litter evaluation on GD18 showed that supplementation of

 reversed the prevalence of microcephaly induced by 

An experimental study on the effects of ethanol and folic acid deficiency, alone or in combination, on pregnant Swiss mice

Down‐regulation of reduced folate carrier may result in folate malabsorption across intestinal brush border membrane during experimental alcoholism

 in intestinal brush border membrane was observed over the course of 

Response of the exocrine pancreas to the CCK on offspring rats of ethanol dams. Effects of folic acid.

 supplementation increased these parameters with respect to 

Kinetic characteristics of folate binding to rat renal brush border membrane in chronic alcoholism

 to the membrane vesicles: (1) was decreased by a mechanism that decreased Bmax without affecting Kd, (2) was insensitive … Na+ ions in the medium (3) behaved differently to divalent cations in the medium in contrast to control group.

Effects of ethanol and folic acid consumption during pregnancy and lactation on basal enzymatic secretion in the duodenal juice of offspring rats.

Although extrapolation from animal studies can be tenuous, the present findings may explain the use of

 to increase the amylase levels to physiologic concentrations.

 were slightly attenuated in rats supplemented with 

Folate absorption in the jejunum of chronic ethanol-fed rats: in vivo studies.

 absorption was higher than in control rats.

Nootropic compound l-pyroglutamyl-d-alanine-amide restores hippocampal long-term potentiation impaired by exposure to ethanol in rats

 (0.5 microM) also prevented the … in hippocampal slices perfused with 

, 20 or 50 mM. The data indicate that PGA effectively restores synaptic plasticity after both prenatal and acute … suggest that impaired LTP may be a useful model for studying the mechanisms of action of nootropic compounds.

Characteristics of the transport of pteroylglutamate and amethopterin in rat jejunum.

 (3g/dl) has a mild inhibitory effect on 

Inhibition of Alcohol Dehydrogenase by Folic Acid and Several of Its Analogs.∗

Folic acid reduces the ethanol-induced morphological and behavioral defects in embryonic and larval zebrafish (Danio rerio) as a model for fetal alcohol spectrum disorder (FASD).

 exposure produced several teratogenic and behavioral defects, 

 reduced, but did not totally prevent, these defects.

Small amounts of ethanol attenuate folic acid stability in acidic beverages during storage

, which surrounds FA molecules in solution due to selective solvation.

Effect of folic acid in prenatal alcohol induced behavioral impairment in Swiss albino mice

 administration reduced the intensity of these effects of 

Folic acid supplementation reduces oxidative stress and hepatic toxicity in rats treated chronically with ethanol

The results indicate that moderately elevated Hcy is associated with increased oxidative stress and liver injury in alcohol-fed rats, and suggests that

 supplementation appears to attenuate hepatic toxicity induced by 

 consumption possibly by decreasing oxidative stress.

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Possible Interaction: Ethanol and Folic Acid

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