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Last Updated: 3 years ago

Possible Interaction: Ethanol and Fluvastatin



Research Papers that Mention the Interaction

Alcohol or orange juice and the fluvastatin were ingested more than 2 hours after the evening meal and within 1 hour of ingestion of the fluvastatin.
Because half-life could be analyzed in only 15 patients and a carryover effect could not be excluded, we can only conclude that concomitant use of alcohol might prolong the terminal half-life of fluvastatin.
In the first treatment period, the half-life was longer for fluvastatin with alcohol (103.9 7.1 minutes) than for fluvastatin alone (81.7 4.8 minutes; P = 0.044).
Six weeks of therapy with fluvastatin (40 mg/d) alone or combined with alcohol resulted in nearly identical decreases in levels of total cholesterol (22% and 23%, respectively), LDL cholesterol (28% and 29%, respectively), and apolipoprotein B (17% and 20%, respectively).
The longer Tmax of fluvastatin in patients consuming alcohol , which reflects prolonged absorption, may be explained by delayed gastric emptying during alcohol consumption [20].
Annals of Internal Medicine  •  1995  |  View Paper