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“ Flurbiprofen 4′-hydroxylation was subject to strong, weak and moderate inhibition by TAAQ (IC50: 34.67 ± 1.38 µg/ml), TAE (IC50: ≥ 50 µg/ml) and EL (IC50: > 50 µg/ml), respectively.”
European Journal of Drug Metabolism and Pharmacokinetics • 2017 | View Paper
“Addition of ethanol increases the critical micellization concentration of the Pluronics (making the polymer more soluble), while increasing the repulsive interactions between the flurbiprofen-Pluronic spherical complexes.”