Possible Interaction: Ethanol and Fluorides

“Pretreatment of rats with pyridine and ethanol , inducers of P450 2E1, increased the rates of fluoride release.”

“ Ethanol also potentiated the response to fluoride , which acts directly on G-proteins.”

“The “pretreat-ments” of the cells with both ethanol and fluoride decreased their acid production capability.”

“Rats exposed to fluoride together with ethanol for 6 weeks resulted in 130% increase in LPO and decrease in the reduced glutathione levels.”

“These results suggest that exposure to fluoride together with ethanol enhances lipid peroxidation by affecting antioxidant defence systems in the rat brain.”

“The observed changes in lipid peroxidation, reduced glutathione levels, and enzyme systems were further augmented in intestine of rats exposed to fluoride and ethanol together.”

“ Ethanol also inhibited amylase release in response to fluoride , a direct activator of guanine nucleotide-binding protein, suggesting that ethanol affects intracellular signal transduction molecules.”

“The concentration of fluorescent products in the brain structures of rats treated perinatally with ethanol was several-fold increased as compared with controls.”

“ Ethanol decreased the Hill coefficient and apparent affinity for inhibition of phosphatase activity by fluoride ion while dimethylsulfoxide had the opposite effects.”

“ Ethanol is most potent at activating the fluoride- and glucagon-stimulated activities whilst having little effect on basal activity.”

“The introduction of ethanol solvent significantly enhances the content of surface chemisorbed F- on the TiO2 nanosheet, which has a higher stability and further lowers the surface energy of {001} facets, giving rise to the large percentage of active {001} facets.”