Possible Interaction: Ethanol and Flunitrazepam

“ Flunitrazepam plus alcohol impaired significantly standing steadiness, tracking, and reactive skills when compared with all other treatments.”

“ Flunitrazepam plus alcohol impaired significantly standing steadiness, tracking, and reactive skills when compared with all other treatments.”

“Chronic exposure to ethanol resulted in a decrease in muscimol-stimulated 36Cl- flux and a decrease in modulation of that flux by ethanol, flunitrazepam , methyl-6,7-4-dimethoxy-4-ethyl-beta-carboline-3-carboxylate and pregnanolone without any change in the modulation by pentobarbital or zinc.”

“Reduction of the action of muscimol, ethanol and flunitrazepam differed in the duration and amount of ethanol required to see an effect.”

“We have also noted the combined abuse of FZ with, for example, alcohol in male forensic psychiatric patients.”

“ Flunitrazepam , widely known by its trade names (e.g. Rohypnol), may cause severe violence, especially in combination with alcohol.”

“ FZ is also associated with loss of episodic memory and with impulsive violence, particularly when combined with alcohol.”

“The presence of ethanol reduces the amount of flunitrazepam needed to cause death.”

“The combination of flunitrazepam and alcohol impaired tracking in a divided attention task the following morning.”

“The largest increase in aggressive behavior occurred after combined flunitrazepam plus ethanol treatment in mice and rats.”

“Thus, motor activity and fear conditioning results demonstrated that both the amount of FLU left unbound by antibody and the pharmacological additivity between FLU and EtOH , a GABA mimetic, were limiting factors in the therapeutic efficacy of mAb RCA3A3.”

“To substantiate this finding, a dose-response study was performed, and the changes in locomotor activity incurred by different FLU (low-dose, 0.06 …), and mAb RCA3A3 (14.5 mg/kg, 21.8 mg/kg) dose combinations illustrated the potentiation in motor effects by concomitant exposure to FLU … EtOH.”