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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Ethanol
drug:
Flumazenil
Research Papers that Mention the Interaction
“However, their suggestion that previous alcohol or benzodiazepine exposure could result in anxiogenic responses to flumazenil are but two in a range of possible causes.”
Chronic use of alcohol and/or benzodiazepines may account for evidence of altered benzodiazepine receptor sensitivity in panic disorder.“This report reflects a possible role for flumazenil in reversing the respiratory depression produced by ethanol ingestion.”
“However, when SMEtOH co-administered with flumazenil or WAY-100635, the anxiolytic effect of SMEtOH was significantly counteracted.”
Anxiolytic effect of an extract of Salvia miltiorrhiza Bunge (Danshen) in mice.“These observations are the first molecular and functional evidence that show a selective inhibition by flumazenil of the up‐regulation of α4‐subunit expression elicited by ethanol withdrawal.”
“We here report that flumazenil prevented both the ethanol withdrawal‐induced up‐regulation of the α4‐subunit and the increase in its own modulatory action.”
“These data are discussed in relation to the possible mechanism(s) by which Ro-15-4513 and flumazenil exert their antagonism on ETOH self-administration.”
“When flumazenil was given alone, both doses reduced ETOH self-administration at 60 min; although the magnitude of the antagonism was comparable to that of Ro15-4513 only with the highest does of flumazenil (16.0 mg/kg).”
“Flumazenil did not affect ETOH-induced increases in locomotion; however, ETOH and flumazenil appeared to show agonistic effects on exlporation.”
“Both ZK 93426 (3 mg/kg) and flumazenil (10 mg/kg) blocked the aggression-enhancing effects of alcohol in dominant squirrel monkeys and resident rats in confrontations with conspecifics.”
“In fact, flumazenil potentiated the effects of low doses of alcohol.”
“Diazepam increased and flumazenil decreased ethanol consumption significantly by about 30%.”
“Rationale: Administration of flumazenil , a benzodiazepine (BZD) antagonist, has therapeutic efficacy against some anxiogenic effects of ethanol withdrawal.”
“Results: Flumazenil (5.0 mg/kg) significantly reduced the number of ultrasonic vocalizations observed following withdrawal from chronic ethanol.”
“However, flumazenil (10-50 mg/kg) failed to reverse the antihyperalgesic effect of either diazepam or ethanol.”
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