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Last Updated: 3 years ago

Possible Interaction: Ethanol and Flibanserin



Research Papers that Mention the Interaction

Because of the increased risk of hypotension‐ and syncope‐related adverse events (AEs) observed with coadministration of flibanserin and alcohol , alcohol use is contraindicated.
Journal of clinical pharmacy and therapeutics  •  2017  |  View Paper
Despite statistically significant effects on sexual desire, sexual distress, and sexually satisfying events, side-effects are significant, and flibanserin is completely contraindicated with alcohol.
Frontiers in Neuroendocrinology  •  2017  |  View Paper
Although infrequent, hypotension and syncope remain safety concerns because of possible interaction of flibanserin with alcohol.
The journal of sexual medicine  •  2019  |  View Paper
Nonpharmacological treatments may be particularly appropriate for women who have significant psychological and/or dyadic contributors to their low desire, or simply cannot take flibanserin due to its serious interactions with alcohol and medications such as CYP3A4 inhibitors or other chronic medical conditions such as hepatic impairment.
Journal of sex & marital therapy  •  2017  |  View Paper
Safety concerns centered on the incidence of sedation, syncope, hypotension, and the interaction of flibanserin with alcohol and CYP3A4 inhibitors.
Sexual medicine reviews  •  2017  |  View Paper
According to the FDA, about 10% more premenopausal women taking the approved dose (100 mg) of … increased somonolence, sedation, or fatigue compared with placebo: 21% vs 8%.4 Perhaps most importantly, combining flibanserin … alcohol (and other common drugs) can cause dangerous hypotension … most serious safety alert, on the label.
JAMA internal medicine  •  2016  |  View Paper
A variety of safety concerns were raised during the 2013 FDA review, including a risk of hypotension, syncope, and somnolence among users of the product, as well as the potential for adverse effects when flibanserin is taken with alcohol or CYP3A4 inhibitors such as oral contraceptives or fluconazole.
JAMA  •  2015  |  View Paper
Introduction Flibanserin , a treatment for hypoactive sexual desire disorder, carries warnings for increased risk of severe hypotension and syncope when used with alcohol.
Sexual medicine  •  2019  |  View Paper