Possible Interaction: Ethanol and Fish Oils

“To The Editor: In a dose-related fashion intragastric fish oil (10, 100, or 1000 ~1) administered 30 min before intragastric ethanol significantly enhances the resistance of the gastric mucosa against injury (1).”

“Our results demonstrated that fish oil significantly reduced the chronic alcohol exposure‐induced aberrant dendritic morphologic changes of the medium‐sized spiny neurons in the core and the shell of nucleus accumbens.”

“ FO significantly reduced the severity of ulceration in gastric ulcers induced by aspirin, cold-restraint stress (CRS), alcohol , and pylorus ligation.”

“The findings in this letter are unique because a single intragastric treatment of fish oil administered 30 min before intragastric ethanol significantly enhances the resistance of the gastric mucosa against injury; thus, the protective effect of fish oil appears to be dose-related and”

“To The Editor: In a dose-related fashion intragastric fish oil (10, 100, or 1000 ~1) administered 30 min before intragastric ethanol significantly enhances the resistance of the gastric mucosa against injury (1).”

“Results: The diets containing FO and PO retarded ethanol metabolism compared to the diets containing CO and SO.”

“RESULTS In rats that were fed al ohol plus fi s h oil, b iliary concentrations of trapped radicals, which most likely originated from lipids, were 6-fold higher than in controls that were fed fish oil plus dextrose.”

“Level of nonprotein thiols was increased by ethanol feeding to rats given CO or FO.”

“Thus it is suggested that fish oil in the diet prevents hyperlipoproteinemia caused by alcohol possibly by reducing the synthesis and secretion of VLDL by liver.”

“ Fish oil has been shown to counteract many of the adverse effects of ethanol.”