supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Ethanol
drug:
Fenclonine
Research Papers that Mention the Interaction
“The effect of ethanol on the startle response was potentiated by pretreatment of the animals with pimozide, haloperidol, and p-chlorophenylalanine but not by propranolol, phenoxybenzamine, alpha-methyltyrosine, or pargyline.”
The startle response in rats: effect of ethanol“Recently, Myers and c o w o r k e r ~ ~ ~ , ~ ~ ~ ~ ~ suggested that the metabolism of … 5-hydroxytryptamine (SHT) may be a factor in an animal's selection of ethanol because p-chlorphenylalanine , a drug that lowers the brain 5HT …,21 reduced the voluntary intake of ethanol in rats.”
“Preference for ethyl alcohol was significantly reduced or totally abolished in rats given orally p-chlorophenylalanine , a tryptophan hydroxylase inhibitor that selectively depletes brain serotonin.”
“Prazosin (62.5 microg/kg, ip; an alpha1-adrenoceptor antagonist), sulpiride (50 mg/kg, ip; a selective D2 receptor antagonist) and p-chlorophenylalanine (100 mg/kg, ip; an inhibitor of serotonin synthesis) significantly attenuated the aqueous and ethanolic extract-induced antidepressant-like effect in TST.”
“This study extends our findings with respect to the inhibitory effect of p-CPA on the development of tolerance to the motor-impairing effects of ethanol , and suggests that 5-HT may have a role in tolerance development to ethanol.”
“Depletion of 5-HT by p-CPA also blocked acute tolerance to ethanol.”
“IMI and less markedly AMI increased ethanol narcosis and antagonized the effect of PCPA.”
“ PCPA and AMPT pretreatment significantly reduced and prolonged respectively, ethanol narcosis but did not modify the effect of pentobarbital.”
“Chronic administration of p-chlorophenylalanine (p-CPA), in a dose previously shown to maintain more than 95% depletion of brain serotonin (5-HT), enhanced the acute hypnotic effect of barbiturates and ethanol.”
“This study extends our previous findings with respect to the inhibitory effects of p-CPA on tolerance development to ethanol and pentobarbital, and suggests that 5-HT may play a role in cross-tolerance development between ethanol and pentobarbital.”
Effect of p-chlorophenylalanine on development of cross-tolerance between pentobarbital and ethanol.“Administration of L-DOPA and pCPA , together, produced a smaller augmentation of ethanol effects.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback