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Possible Interaction: Ethanol and Felodipine

supplement:

Ethanol

Research Papers that Mention the Interaction

Adverse effects were frequent but most often occurred with felodipine plus ethanol (17 vs 11) as a result of postural lightheadedness (5 vs 1) related to hypotension.
Ethanol can enhance felodipine hemodynamics to produce clinically relevant adverse effects.
Felodipine … ethanol decreased mean (+/- SE) supine total peripheral resistance (13 +/- 2 vs 17 +/- 2 mmHg/L/min, p = 0.05) and diastolic blood pressure (68 +/- 3 … cardiac index (3.7 +/- 0.4 vs 3.0 +/- 0.3 L/min/m2, p less than 0.05) more than felodipine alone.
Clinical and investigative medicine. Medecine clinique et experimentale  •  1989  |  View Paper
After chronic administration of the felodipine , administration of an acute dose of ethanol resulted in an increase in locomotor activity, but this was not seen after chronic administration of nitrendipine or vehicle.
Felodipine had a small potentiating effect on the general anesthetic effects of ethanol , but was considerably less effective in this respect than nitrendipine.
In the locomotor studies, both felodipine and nitrendipine significantly decreased the locomotor stimulation produced by ethanol ; the effects of the two compounds were similar, but dose-dependency was not seen at the doses tested.
Some potentiation of the ataxic effect of ethanol was seen after concurrent administration of felodipine , but this was less than that seen after nitrendipine.
The results, therefore, suggest that felodipine was considerably less effective in potentiating the acute effects of ethanol than nitrendipine at doses that were equi-effective in displacing central dihydropyridine binding.
Brain Research Bulletin  •  1998  |  View Paper
Ethanol lowered the GMBF and produced gastric mucosal lesions, and these actions were potentiated by felodipine.
It is concluded that felodipine aggravates ethanol ulceration through a depressive action on the GMBF.
Pharmacology  •  1995  |  View Paper
Felodipine (10 mg kg-1, twice daily) during the course of ethanol treatment also failed to attenuate the withdrawal syndrome.
Suggested explanations for the results include the possibility that nitrendipine may protect against the ethanol withdrawal syndrome via sites other than dihydropyridine receptors: that felodipine has partial agonist actions at dihydropyridine receptors in the CNS or that felodipine has actions which mask its protective effect in ethanol withdrawal.
The convulsive response to a mild audiogenic stimulus during ethanol withdrawal was increased following one dose of felodipine (5 mg kg-1, i.p.)
British journal of pharmacology  •  1994  |  View Paper