Possible Interaction: Ethanol and Famotidine

“ Famotidine increased the area under the plasma ethanol concentration‐time curve (AUC0‐t) by 29% (7.1 vs 5.5 mg.h/dL, P= 0.006) and maximal plasma concentration (Cmax) by 23% (9.2 vs 7.5 mg/dL, P= 0.013).”

“Expert opinion: At doses of 0.15–0.30 mg/kg in the postprandial state (primarily after breakfast), the H2-receptor antagonists: cimetidine, ranitidine, famotidine , and nizatidine have all been found to increase the first-pass metabolism of ethanol.”

“In the famotidine group , the healing rate was significantly lower in patients who drink alcohol than in those who do not (60.0% vs. 91.2%; p = 0.0119).”

“In vivo, therapeutic doses of cimetidine (but not of famotidine ) increased blood ethanol levels when ethanol was given orally, but not when it was given intravenously, indicating a significant contribution of the gastric ADH to the bioavailability and thereby the potential toxicity of ethanol.”

“In addition, famotidine increased the transgastric potential difference (PD) and promoted the recovery of decreased transgastric PD induced by acidified ethanol in rats.”

“On the other hand, famotidine inhibited the decreases of gastric mucosal blood flow induced by acidified ethanol and the mucosal contents of glycoprotein induced by water immersion restraint stress.”