Possible Interaction: Ethanol and Estradiol

“ Alcohol significantly enhanced naloxone stimulation of prolactin and estradiol.”

“Our results revealed that 17β-estradiol treatment before and after ethanol decrease expression of occludin and claudin-1 and value of TEER which are BBB disrupt indicators.”

“In vivo flux of estradiol in ethanol or ethanol solutions across viable human skin was increased with saturated solutions of estradiol.”

“Furthermore, it has been reported that plasma levels of estradiol , progesterone and testosterone increase during alcohol treatment in the midluteal phase, while gonadotropins tend to decrease.”

“In contrast, among rats exposed for 10 weeks, there was a significant positive correlation between ethanol dose and both uterus weight and estradiol ; analysis of variance demonstrated that inclusion of the data obtained from rats receiving the 5.5% ethanol dose accounted for the significance of these associations.”

“Further experimental evidence in rats suggest that such commonly used drugs as analgesic acetylsalicylic acid, antimalarial chloroquine phosphate and alcohol also alter the intestinal mucosal metabolism of estradiol and estrone sulphate and may thus alter the bioavailability of these estrogens.”

“Among female adolescents with later bedtimes, higher estradiol was associated with higher behavioral domain risk (specifically alcohol and substance use).”

“Our prospective data suggested that baseline concentrations of estradiol , with or without SHBG, might influence the alcohol –T2D association in postmenopausal women.”

“There is recent evidence that estradiol attenuates the effects of ethanol in osteoblasts but that ethanol impairs estrogen receptor signaling (10).”

“ Alcohol may decrease the metabolic clearance of estradiol , whereby the risk of breast cancer associated with hormone use may depend on blood alcohol levels.”