Possible Interaction: Ethanol and Epigallocatechin Gallate

“For hepatoprotective activity in vitro, it was observed that EGCG3″Me effectively alleviated the changes induced by alcohol in a concentration-dependent manner.”

“ EGCG can prevent some of the embryonic injuries caused by ethanol.”

“It was concluded that green tea catechins can enhance the excretion of UA and Xa/HX, even though alcohol is ingested.”

“Moreover, this slight aggregation of II-I in the presence of EGCG was disrupted by the addition of 12% ethanol.”

“ EGCG failed to prevent the intracellular glutathione loss caused by ethanol , but it appeared to be a strong GGT inhibitor.”

“Compared with an ethanol group, when EGCG was present in the ethanol diet, the formation of a fatty liver was significantly reduced and the serum aspartate transaminase (AST) and alanine transaminase (ALT) levels were much lower.”

“While EGCG markedly reversed the effect of ethanol on hepatic p-ACC and CPT-1 levels, it had no effect on the ethanol-induced elevation in CYP2E1 expression.”

“ Tea catechin (100, 200 mg/kg orally) markedly inhibited the increase in thiobarbituric acid-reactive substances in the injured mucosa of rats treated with 50% ethanol.”

“Under the optimal condition, the content of EGCG in the 30% ethanol eluent increased by 5.8-fold from 7.7% to 44.6%, with the recovery yield of 72.1%.”

“Coadministration of EGCG along with ethanol significantly reduced the levels of liver lipids and collagen, improved the solubility properties of collagen, and caused a reduction in cross-linking as evidenced by a decrease in fluorescence, peroxidation, and aldehyde content.”

“The detrimental effects of ethanol were alleviated upon simultaneous treatment with EGCG (100 mg/kg/day) for the last 30 days of alcohol feeding.”