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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Ethanol and Elvitegravir



Research Papers that Mention the Interaction

Presence of ethanol demonstrated a significant effect on the total exposures of both EVG and EVG in combination with COBI.
PloS one  •  2017  |  View Paper
Docking studies predicted a shift of EVG or COBI binding to the active site of CYP3A4 in the presence of ethanol.
Inhibition studies demonstrated that EVG inhibits CYP3A4, and 20 mM ethanol causes a decrease in the IC50 of EVG.
Our substrate kinetic results revealed that ethanol mildly decreases the catalytic efficiency for EVG metabolism.
Taken together, these results suggest that ethanol interacts with microsomal CYP3A and alters EVG-CYP3A4 interaction thereby altering EVG metabolism and inhibition of CYP3A4 by EVG.
Time dependent kinetics data showed that 20mM ethanol decreases the apparent half-life of EVG degradation by ~50% compared to EVG alone.
PloS one  •  2016  |  View Paper
Our previous reports have shown that ethanol reduced intracellular concentrations of antiretroviral drugs elvitegravir and darunavir in the HIV-1-infected U1 cell line.
Biochemistry and biophysics reports  •  2019  |  View Paper