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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Ethanol and Ecgonine



Research Papers that Mention the Interaction

Ethanol pretreatment resulted in 2- to 3-fold increases in peak hepatic concentrations of cocaine, ecgonine methyl ester, and the N-oxidative metabolite norcocaine, and the areas under the hepatic concentration vs. time curve (AUCs) for these compounds were doubled.
Drug metabolism and disposition: the biological fate of chemicals  •  1993  |  View Paper
Ethanol decreases the clearance of cocaine by inhibiting the hydrolysis of cocaine to benzoylecgonine and ecgonine methyl ester by carboxylesterases, and there is a large body of literature describing this interaction as it relates to the abuse of cocaine.
Drug Metabolism and Disposition  •  2010  |  View Paper