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Last Updated: 2 years ago

Possible Interaction: Ethanol and Ebselen





Research Papers that Mention the Interaction

After 4 weeks, serum ALT levels were increased significantly about 4-fold over control values (37 +/- 5 IU/l) by enteral ethanol (112 +/- 7 IU/l); ebselen blunted this increase significantly (61 +/- 8 IU/l).
While there were no significant effects of either ethanol or ebselen on glutathione peroxidase activity in serum or liver tissue, ebselen blocked the increase in serum nitrate/nitrite caused by ethanol.
Free radical biology & medicine  •  2001  |  View Paper
Histologically, mucosal injury following ebselen exposure together with ethanol was less severe compared with ethanol treatment alone.
Therefore, ebselen exhibited a beneficial effect by increasing the gastric ethanol metabolism and by ameliorating the possible tissue toxicity of ethanol.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements  •  1999  |  View Paper
Addition of ebselen (10 and 100 microM) to this system (15% ethanol ) significantly inhibited the cell damage and completely prevented the increase in lipid peroxide level.
European journal of pharmacology  •  1995  |  View Paper
Simultaneous infusion of ebselen at a concentration of 10 or 30 microM with ethanol reduced significantly this ethanol-induced increase in portal pressure by 50 to 75% (P < .05) and LDH release by 70% (P < .05).
The Journal of pharmacology and experimental therapeutics  •  1994  |  View Paper