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Last Updated: 4 months ago

Possible Interaction: Ethanol and Doxepin

supplement:

Ethanol

drug:

Doxepin

Research Papers that Mention the Interaction

Amitriptyline in combination with alcohol increased cumulative choice reaction times, and doxepin in combination with alcohol increased both cumulative choice reaction times and inaccuracy of reactions.
It seems as if doxepin and amitriptyline but not nortiriptyline or chlorimipramine, in combination with 0.5 gm/kg of alcohol , may be especially dangerous in driving.
Clinical pharmacology and therapeutics  •  1975  |  View Paper
It seemed that the antianxiety effects of doxepin were to some extent antagonistic to the well- documented detrimental effect which alcohol has on the performance of these tasks.
The Medical journal of Australia  •  1973  |  View Paper
In general, the interference of doxepin with ethanol was more pronounced after single doses of the drug than after chronic treatment.
Polish journal of pharmacology and pharmacy  •  1991  |  View Paper
Only desipramine, 5 and 10 mg/kg, metapramine, 10 mg/kg, clomipramine, 5 and 10 mg/kg and doxepin , 10 mg/kg, were able to reduce significantly the ethanol intake.
Alcohol  •  1984  |  View Paper