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Last Updated: 4 months ago

Possible Interaction: Ethanol and Disulfiram

supplement:

Ethanol

Research Papers that Mention the Interaction

The most commonly prescribed agents are the aversive drugs (e.g., disulfiram , calcium carbimide), which when ingested prior to alcohol produce an unpleasant physiologic reaction, which is supposed to deter further drinking.
Addictive behaviors  •  1981  |  View Paper
The therapeutic rationale for using implanted disulfiram is possible inhibition of the liver enzyme acetaldehyde dehydrogenase, producing an acetaldehyde-mediated aversive reaction after intake of ethanol.
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke  •  1990  |  View Paper
Finally, in view of the low (approximately 0.5) probability with which a DER follows ingestion of alcohol by a disulfiram implant patient, it is suggested that the approach to patient management should be changed to maximize the effectiveness of the disulfiram implant procedure.
Canadian journal of psychiatry. Revue canadienne de psychiatrie  •  1979  |  View Paper
In contrast to anti-craving drugs, disulfiram does not modulate neurobiological mechanisms of addiction, but rather works by producing an aversive reaction when combined with alcohol.
Pharmacopsychiatry  •  2016  |  View Paper
In vitro permeability was measured unidirectionally in Caco-2 and MDCKII cell models in the presence of acetaldehyde, ethanol, or disulfiram , an aldehyde dehydrogenase inhibitor, which causes acetaldehyde formation when coadministered with ethanol in vivo.
Journal of Pharmacology and Experimental Therapeutics  •  2010  |  View Paper
Disulfiram was first used clinically in an attempt to deter people from ethanol consumption (Hald and Jacobsen, 1948).
Advances in experimental medicine and biology  •  1997  |  View Paper
Disulfiram , an acetaldehyde dehydrogenase inhibitor, enhanced the inhibitory effect of ethanol in vivo.
Carcinogenesis  •  1988  |  View Paper
Following co-administration of ethanol and an inhibitor of acetaldehyde metabolism, such as disulfiram or calcium carbamide, acetaldehyde blood concentrations may increase 5-10 fold over normal level (reviewed in [1]).
Report on carcinogens : carcinogen profiles  •  1985  |  View Paper
Pretreatment with disulfiram potentiated the effect of ethanol.
Pharmacology Biochemistry and Behavior  •  1980  |  View Paper
The symptoms are similar to those obtained when ethanol is taken with disulphiram (antabuse) which acts by inhibiting acetaldehyde metabolism.
European journal of clinical investigation  •  1978  |  View Paper
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