Possible Interaction: Ethanol and Dinoprostone

“Simultaneously, ethanol reduced the induction of IL-6 and increased prostaglandin E2 synthesis as well as hPDL-fibroblast-mediated osteoclastogenesis without affecting the RANK-L/OPG-system.”

“Inhibition of ethanol metabolism, blockage of Src activity, or inactivation of TLR4 prevented the activation of cPLA2 and COX-2 as well as diminished PGE2 production, suggesting that interactive phosphorylation of TLR4–Src regulated the pro-inflammatory response in astrocytes.”

“In this study, it was investigated whether alcohol misuse impairs the synthesis of prostaglandin E2 (PGE2) and prostaglandin F2 alpha (PGF2 alpha) in gastric mucosa.”

“Various alcohol concentrations cause an increase in LTC4 and PGE2 in healthy volunteers; we observed no LTC4 increase in alcoholics and although PGE2 levels increased after 20% ethanol, they remained constant at higher ethanol concentrations.”

“Further analysis demonstrated that ethanol inhibits the production of interleukin‐1 β (IL‐lβ) and induces transforming growth factor β (TGF‐β) and prostaglandin E2 (PGE2), monocyte‐derived mediators that can affect T cell proliferation.”

“The amount of prostaglandin E2 was reduced when dialysers were pre-washed with alcohol.”

“ PGE2 production was also enhanced by exposure of endothelial cells to ethanol.”

“ Prostaglandin E2 (PGE2) by itself (1 mg/50 ml) had no stimulatory effect on DNA synthesis; it did, however, reduce the drastic fall in DNA synthesis due to ethanol (p less than 0.005) when administered concomitantly.”

“of 10 per cent ethanol per hour for one hour inhibited uterine activity initiated and maintained by an infusion of either prostaglandin E2 or prostaglandin F2α.”

“The results revealed that ethanol decreased SOD, GPx and PGE2 in tissue and serum total protein and albumin, while increased MDA in tissue, serum TNF-α, IL-B1, PGE2, ALT, AST, ALP.”