Possible Interaction: Ethanol and Dinoprost

“Further, we have measured the influence of ethanol administration on renal clearance of the 15-keto metabolite of PGF2 alpha in an attempt to determine the in vivo significance of the enzyme inhibition observed in vitro.”

“In this study, it was investigated whether alcohol misuse impairs the synthesis of prostaglandin E2 (PGE2) and prostaglandin F2 alpha (PGF2 alpha) in gastric mucosa.”

“of 10 per cent ethanol per hour for one hour inhibited uterine activity initiated and maintained by an infusion of either prostaglandin E2 or prostaglandin F2α.”

“The present results, using isolated rat aortic strips and portal vein segments, demonstrate that ethanol , depending upon concentration, can either enhance or attenuate the contractile actions of PGF2α on at least 2 different types of vascular smooth muscle.”

“The resting level of [Ca2+]i in the cerebral vascular …. Exposure of these cells to 10 and 25 mM ethanol for 5 days resulted in significant elevation of [Ca2+]i (mean rises to 208 +/- …), and potentiated the transient rise in [Ca2+]i induced by 10(-7) M PGF2 alpha.”

“ Alcohol increased uterine PGE and PGF2alpha , with PGE levels higher than control before labour, and elevated PGF2alpha levels correlating with labour.”

“ PGF2 alpha stimulated PtdEt accumulation at concentrations of more than 100 nM in the presence of ethanol.”

“Exposure to 100% ethanol (with and without mild irritant pretreatment) significantly increased prostanoid synthesis (especially PGI2, PGF2 alpha , and PGE2) compared with stomachs exposed to water or 25% ethanol alone; only mild irritant treated mucosa was protected from injury by 100% ethanol.”

“At 2.5% ethanol , the production of PGF2 alpha and PGE2 in sublingual gland decreased by 10% and reached maximum inhibition at 5% ethanol, at which concentration there was a 20 and 30% decrease in their levels.”

“In In the sublingual gland, ethanol caused a decrease in PGE2 and PGF2 alpha levels, but had no effect on 6-keto-PGF1 alpha, while all three prostaglandins were affected in the submandibular gland.”

“In submandibular gland, 2.5% ethanol caused a 20% decrease in PGE2, 30% in PGF2 alpha and 50% in 6-keto-PGF1 alpha; 40% inhibition in PGE2, 57% in 6-keto-PGF1 alpha and 65% in PGF2 alpha occurred in the presence of 5% ethanol.”

“Five percent ethanol significantly increased 6-keto-PGF1 alpha, PGF2 alpha , and PGE2 levels.”