Possible Interaction: Ethanol and Dimethyl Sulfoxide

“Moreover, if DMSO was administered in cases of an already existing effect of alcohol , a fourfold increase of mortality resulted.”

“When simultaneous doses of both materials were administered, small doses of DMSO reduced the mortality expected as a result of the alcohol from 50 to 37 per cent.”

“When, however, an already existing effect of DMSO was met by alcohol , the mortality was doubled.”

“ Ethanol and dimethylsulfoxide , solvents commonly used to prepare chemicals for testing, weakly inhibited metabolic cooperation.”

“The effects of ethanol were mimicked by propanol, dimethylsulfoxide and to a lesser extent methanol.”

“The enhancement of DPH fluorescence polarization produced by DMSO was antagonized by the concomitant addition of ethanol.”

“Treatment … DMSO significantly (p … of the ethanol injury (11.1 +/- 0.8 and 11.9 +/- 0.9 mm2, respectively, vs. 19.2 +/- 1.1 mm2, n = 10) and … 5% solutions (10.4 +/- 0.9 and 10.2 +/- 0.8 mm2, respectively, vs. 19.2 +/- 1.1 mm2, n = 10).”

“ DMSO markedly attenuated this response in the normotensive and hypotensive ethanol groups.”

“ Dimethyl sulfoxide also mimicked the effect of ethanol to increase cAMP (P less than 0.001). (”

“ Dimethyl sulfoxide competitively inhibited ethanol oxidation in imidazole-induced microsomes; it was a noncompetitive inhibitor of ethanol oxidation in phenobarbital- or beta-naphthoflavone-induced microsomes.”

“ Dimethylsulfoxide at concentrations that inhibited the oxidation of ethanol had no effect on the xanthine oxidase-mediated oxidation of ethanol or on aniline hydroxylase or aminopyrine demethylase activity of microsomes.”

“ Dimethylsulfoxide , benzoate, mannitol and thiourea, four compounds that react rapidly with hydroxyl radicals, each inhibited the oxidation rate of ethanol.”

“Moreover, Ramachandran plot analysis indicated that the PPL structure quality in DMSO was higher than that in PRG and EtOH.”