Possible Interaction: Ethanol and Dihydroxyphenylalanine

“of ethanol significantly increased the levels of L-DOPA to 60% above the control value.”

“ Ethanol caused a dose-dependent accumulation of DOPA in the corpus striatum after inhibition of DOPA-decarboxylase suggesting an increased synthesis of DA.”

“Maximum brain levels of THP, dopa, and dopamine in animals administered ethanol plus L‐dopa as compared with L‐dopa‐treated animals repressented a 1048%, 325%, and 84% increase, respectively.”

“The specific activity of 3,4‐dihydroxyphenylalaninedecarboxylase DOPADC ) was significantly elevated in the brains of prenatal and postnatal EtOH and IC pups, with little difference between the groups.”

“Abstract Acute oral administration of ethanol (3.2g/kg) to normal rats increased DOPAC levels and DOPA formation in the caudate nucleus but had no effect in the substantia nigra and frontal cortex and failed to modify dopamine (DA) levels in any of the above brain areas.”

“A single oral administration … 3.2 g/kg ethanol to normal rats increased 3,…-dihydroxyphenylacetic acid (DOPAC) content and DOPA formation in the caudate nucleus but had no effect in frontal cortex and substantia nigra and did not modify dopamine (DA) levels in any of the brain regions analyzed.”

“Eight hours after a single (3 g/kg) dose of ethanol, DOPA synthesis was increased and pimozide, a dopamine receptor antagonist, stimulated DOPA synthesis to the same degree in ethanol‐treated and control animals.”

“The amount of dopa accumulating in brain as a consequence of decarboxylase inhibition was significantly increased by moderate doses of ethanol (up to 4 g kg−1).”

“Since dopa appears to condense easily with acetaldehyde, forming tetrahydroisoquinoline derivatives (Cohen & Collins, 1970), the choice of ethanol as a scavenger in storing aqueous solutions of labelled dopa may be questionable.”