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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Ethanol
drug:
Dihydrotestosterone
Research Papers that Mention the Interaction
“We … that ethanol and ethyl acetate extracts from C. … and G. lucidum, respectively, selectively inhibit dihydrotestosterone-induced LNCaP cell viability, suppress levels of secreted prostate-specific antigen in a dose-dependent manner, and cause a G1 phase arrest in LNCaP, but not in DU 145 and PC-3 cells.”
Coprinus comatus and Ganoderma lucidum interfere with androgen receptor function in LNCaP prostate cancer cells“UNLABELLED In our previous study we showed that alcohol disturbed the circadian rhythms of LH, testosterone and its conversion to DHT.”
“The amount of alcohol consumed during the day before the blood and saliva sampling shows a significant effect on the DHT metabolism, and the shorter the time after drinking, the greater decrease of DHT and DHT/E2 can be observed.”
“These observations indicate that dihydrotestosterone has a direct suppressant effect on hepatocyte alcohol dehydrogenase and that the enzyme activity is a major determinant of the rate of ethanol elimination.”
Depression of alcohol dehydrogenase activity in rat hepatocyte culture by dihydrotestosterone.“ Dihydrotestosterone was found to be a substrate of liver alcohol dehydrogenase in the reductive direction and a competitive inhibitor of ethanol oxidation by the enzyme.”
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