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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Ethanol
drug:
Diethylstilbestrol
Research Papers that Mention the Interaction
“CONCLUSION(S) Women who were current …, consumed ≥10 g/day of al ohol, w ere … thylstilbestrol in utero, initiated oral contraceptives at earlier than age 16 years (which may be a marker of riskier sexual … had a history of infertility, intrauterine device use, or tubal ligation had a higher risk of EP.”
Demographic, lifestyle, and reproductive risk factors for ectopic pregnancy.“In the presence of ethanol, diethylstilbestrol dose dependently reduced phosphatidylethanol formation induced by chemotactic peptide or by phorbol 12-myristate 13-acetate, indicative of diethylstilbestyrol inhibition of phospholipase D activity.”
“The DES was also more toxic (about 70 times) in the BDL rats when ethyl alcohol was the solvent (0.47 vs 34 mg/kg), and was 5 times more toxic in the BDL rats when administered in propylene glycol (100 vs 530 mg/kg).”
The effect of altered hepatic function on the toxicity, plasma disappearance and biliary excretion of diethylstilbestrol.
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