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Last Updated: 3 years ago

Possible Interaction: Ethanol and Diethyldithiocarbamate

supplement:

Ethanol

drug:

Diethyldithiocarbamate

Research Papers that Mention the Interaction

“ Diethyldithiocarbamate (DDTC), an ALDH inhibitor, elevates blood acetaldehyde levels in the presence of ethanol.”
Concurrent administration of diethyldithiocarbamate and 4-methylpyrazole enhances ethanol-induced locomotor activity: the role of brain ALDH
Psychopharmacology  •  2001  |  View Paper
“Coadministration of ethanol and diethyldithiocarbamate inhibited LPS-stimulated iNOS mRNA, protein and RNI more than either inhibitor alone but did not differ from ethanol alone on autacoid-stimulated iNOS protein or RNI.”
Interaction of ethanol with inducible nitric oxide synthase messenger RNA and protein: direct effects on autacoids and endotoxin in vivo.
The Journal of pharmacology and experimental therapeutics  •  1997  |  View Paper
“In rats treated with DDTC-Me sulfoxide and challenged with ethanol , a small increase of approximately microM in blood acetaldhyde and an inconsistent drop in blood pressure was observed.”
Diethyldithiocarbamate methyl ester sulfoxide, an inhibitor of rat liver mitochondrial low Km aldehyde dehydrogenase and putative metabolite of disulfiram.
Alcoholism, clinical and experimental research  •  1994  |  View Paper
“Disulfiram (DSF) and diethyldithiocarbamate (DDC) completely prevented lipid peroxidation, induced by allyl alcohol , tert-butyl hydroperoxide (t-BHP), diethyl maleate (DEM), bromoisovalerylurea (BIU) and carbon tetrachloride (CCl4).”
Inhibition of lipid peroxidation by disulfiram and diethyldithiocarbamate does not prevent hepatotoxin-induced cell death in isolated rat hepatocytes. A study with allyl alcohol, tert-butyl hydroperoxide, diethyl maleate, bromoisovalerylurea and carbon tetrachloride.
Chemico-biological interactions  •  1988  |  View Paper