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Last Updated: 2 years ago

Possible Interaction: Ethanol and Diclofenac

supplement:

Ethanol

Research Papers that Mention the Interaction

Ethanol at a concentration of 3.0 vol% (510 mM) increased the K(m) value of diclofenac metabolism without changes in the V(max), which indicates that diclofenac 4'-hydroxylation by CYP2C9.1 was competitively inhibited by ethanol.
Biological & pharmaceutical bulletin  •  2009  |  View Paper
The addition of benzyl alcohol , a preservative, in oil drops, increased the Papp value of diclofenac.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan  •  2007  |  View Paper
Higher P and removal of DCF (28.24 ± 1.10%) and IBU (18.72 ± 1.60%) with ethanol was observed for 43.20 ± 0.01 mgDCF L-1 and 43.42 ± 0.03 mgIBU L-1, respectively.
The Science of the total environment  •  2020  |  View Paper