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Possible Interaction: Ethanol and Diazepam

supplement:

Ethanol

Research Papers that Mention the Interaction

Diazepam significantly increased beer consumption, and produced a marginally significant increase in reported desire for alcohol.
The present study investigated whether low-dose diazepam would cross-prime motivation for alcohol in problem drinkers.
Behavioural pharmacology  •  2004  |  View Paper
The tests were carried out before and 1, 3.5 and 5 h after intake of 15 mg diazepam , 30 mg oxazepam, 7.5 mg zopiclone, 15 mg zolpidem or 0.65+0.35 g/kg ethanol , these impaired performance by varying extents.
Journal of psychopharmacology  •  1997  |  View Paper
Despite the absence of significant synergistic interactions, unanticipated impairment of performance may occur in susceptible individuals when taking combined low doses of alcohol and diazepam.
Psychopharmacology  •  1993  |  View Paper
Only two hours after application of ethanol in combination with diazepam , a marked decrease of systolic and diastolic blood pressure was registered in comparison with the values observed after application of placebo.
Acta Universitatis Palackianae Olomucensis Facultatis Medicae  •  1989  |  View Paper
NCR impairment was observed only after application of ethanol with diazepam.
The frequency of responses was impaired only after the combination of ethanol plus diazepam.
Two hours after the administration, the combinations of ethanol plus diazepam and ethanol plus meclophenoxate impaired significantly the number of necessary repetitions.
Acta Universitatis Palackianae Olomucensis Facultatis Medicae  •  1989  |  View Paper
The area under the curve (AUC) for total diazepam increased in all subjects (30.1 +/- 10.7%, mean = SD, p < 0.02) after ethanol.
Clinical pharmacology and therapeutics  •  1980  |  View Paper
Diazepam alone did not impair reactive or co-ordinative skills whereas the combinations of diazepam and alcohol did so.
Acta pharmacologica et toxicologica  •  1979  |  View Paper
Thus, coadministration of diazepam with the ethanol cocktail tended to slow the rate of diazepam absorption, but did not influence the completeness of absorption.
Psychopharmacology  •  1978  |  View Paper
Combined administration of ethanol and diazepam increased the detrimental effects on the tests mentioned above, and also increased the effect on Time Evaluation Ability (not significant) and Complex Coordination (α = 0.04) and Sorting tests (α = 0.055).
Ethanol significantly (α = 0.05) reduced the score in the Minor Tracing Test, and diazepam significantly reduced the score in the Letter Cancellation, Flicker Fusion Frequency, and Mirror Tracing tests, and in the Clinical Examination.
Acta pharmacologica et toxicologica  •  1974  |  View Paper
Alcohol and diazepam potentiated each other's harmfull effects, whilst lithium tended to antagonize the effects of alcohol, except on co-ordination.
Alcohol and diazepam together also had very deleterious effect on psychomotor skills related to driving.
European Journal of Clinical Pharmacology  •  1974  |  View Paper
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