Possible Interaction: Ethanol and Diazepam

“Despite the absence of significant synergistic interactions, unanticipated impairment of performance may occur in susceptible individuals when taking combined low doses of alcohol and diazepam.”

“Thus, coadministration of diazepam with the ethanol cocktail tended to slow the rate of diazepam absorption, but did not influence the completeness of absorption.”

“ Alcohol and diazepam potentiated each other's harmfull effects, whilst lithium tended to antagonize the effects of alcohol, except on co-ordination.”

“ Alcohol and diazepam together also had very deleterious effect on psychomotor skills related to driving.”

“ Diazepam significantly increased beer consumption, and produced a marginally significant increase in reported desire for alcohol.”

“On the reading task, diazepam significantly decreased response latency to Alcohol words relative to Neutral words.”

“The present study investigated whether low-dose diazepam would cross-prime motivation for alcohol in problem drinkers.”

“The tests were carried out before and 1, 3.5 and 5 h after intake of 15 mg diazepam , 30 mg oxazepam, 7.5 mg zopiclone,15 mg zolpidem or 0.65+0.35 g/kg ethanol , these impaired performance by varying extents.”

“Only two hours after application of ethanol in combination with diazepam , a marked decrease of systolic and diastolic blood pressure was registered in comparison with the values observed after application of placebo.”

“NCR impairment was observed only after application of ethanol with diazepam.”

“The frequency of responses was impaired only after the combination of ethanol plus diazepam.”

“Two hours after the administration, the combinations of ethanol plus diazepam and ethanol plus meclophenoxate impaired significantly the number of necessary repetitions.”

“The area under the curve (AUC) for total diazepam increased in all subjects (30.1 ± 10.7%, x̄ = SD, p < 0.02) after ethanol.”

“Diazepam alone did not impair reactive or co-ordinative skills whereas the combinations of diazepam and alcohol did so.”

“Combined administration of ethanol and diazepam increased the detrimental effects on the tests mentioned above, and also increased the effect on Time Evaluation Ability (not significant) and Complex Coordination (α = 0.04) and Sorting tests (α = 0.055).”

“ Ethanol significantly (α = 0.05) reduced the score in the Minor Tracing Test, and diazepam significantly reduced the score in the Letter Cancellation, Flicker Fusion Frequency, and Mirror Tracing tests, and in the Clinical Examination.”