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Possible Interaction: Ethanol and Dexamethasone

supplement:

Ethanol

Research Papers that Mention the Interaction

As a result of these different actions, alcohol could result in either an increase or decrease in dexamethasone CL.
Psychopharmacology bulletin  •  1991  |  View Paper
Neither LhGR-N nor dexamethasone affected seedling development although ethanol retarded development when used as a solvent for dexamethasone.
The Plant journal : for cell and molecular biology  •  2005  |  View Paper
Finally, the use of tween 20 instead of EtOH as chemical enhancer has led to 2-fold factor increase in the flux of dexamethasone , resulting in fluxes convenient for transdermal administration of ondansetron to a child, but insufficient for an adult and for dexamethasone.
International journal of pharmaceutics  •  2016  |  View Paper
Ethanol at a dose of 0.4 g/kg of body weight per day decreased ACE activity in the aorta of aged rats and of rats treated with L-NAME or dexamethasone to the level of activity in young control rats.
It was also found that optimal doses of ethanol increased the number of cells in the thymus of rats treated with dexamethasone.
ethanol dose (the dose inducing a maximum … activity) increased with increasing doses of dexamethasone : 0.4 g/kg of body weight per day at 30 μg of dexamethasone/kg of body weight ….8 g/kg of body weight per day at 100 μg of dexamethasone/kg of body weight.
Clinical science  •  2012  |  View Paper
A reduction of hepatic peroxisome proliferation activator receptor-α (PPAR-α) was associated with coadministration of ethanol and dexamethasone.
Microarray and protein level analyses revealed two distinct changes … hepatic lipid metabolism in mice administered with both ethanol and dexamethasone : accelerated triglyceride synthesis by diacylglycerol O-acyltransferase 2 and suppressed fatty acid β-oxidation by long-chain acyl-CoA synthetase 1, carnitine palmitoyltransferase 1a, and acyl-CoA oxidase 1.
American journal of physiology. Gastrointestinal and liver physiology  •  2013  |  View Paper
Treatment with a general inducing agent such as dexamethasone enhanced ethanol and 2-BE metabolism suggesting induction of multiple ADH isoforms.
Archives of Toxicology  •  2004  |  View Paper
The effects of aldosterone and dexamethasone on (Na+K)-ATPase activity were augmented by ethanol in 50 and 19% of controls, respectively.
These results suggest that ethanol treatment enhances the upregulation of (Na+K)-ATPase activity by both aldosterone and dexamethasone , in cultured renal papillary collecting duct cells.
Endocrine  •  2002  |  View Paper
The rapid blockade of ethanol induced anxiolysis by dexamethasone strengthens the suggestion that a nongenomic mechanism may underlie this response.
Unilateral intrahippocampal injection of dexamethasone (2 and 20 nmol in 0.5 microl) also significantly attenuated the increased exploration of the open arms induced by ethanol.
Pharmacology Biochemistry and Behavior  •  2000  |  View Paper
The finding that E females but not males exhibit elevated ACTH and CORT after DEX administration suggests that prenatal ethanol exposure results in sex-specific alterations of HPA feedback.
Alcoholism, clinical and experimental research  •  2000  |  View Paper
Ethanol treatment produced dose-dependent hypothermia throughout the experiment (-1.84 +/- 0.10, -2.79 +/- 0.09 and -3.79 +/- …/kg ethanol, respectively, 30 min after ethanol) but only the effects of 2.0 and 3.0 g/kg ethanol were significantly antagonized (-0.… ethanol) by pretreatment with dexamethasone (…).
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas  •  1997  |  View Paper
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