Possible Interaction: Ethanol and Dexamethasone

“Finally, the use of tween 20 instead of EtOH as chemical enhancer has led to 2-fold factor increase in the flux of dexamethasone , resulting in fluxes convenient for transdermal administration of ondansetron to a child, but insufficient for an adult and for dexamethasone.”

“ Ethanol at a dose of 0.4 g/kg of body weight per day decreased ACE activity in the aorta of aged rats and of rats treated with L-NAME or dexamethasone to the level of activity in young control rats.”

“It was also found that optimal doses of ethanol increased the number of cells in the thymus of rats treated with dexamethasone.”

“… ethanol dose (the dose inducing a maximum … activity) increased with increasing doses of dexamethasone : 0.4 g/kg of body weight per day at 30 μg of dexamethasone/kg of body weight ….8 g/kg of body weight per day at 100 μg of dexamethasone/kg of body weight.”

“Medications and other substances that can increase serum CK levels include the following: • amphotericin B • ampicillin • aspirin • anticoagulants • dexamethasone • furosemide • morphine • statins • alcohol • cocaine.”

“The 4.4-year survival rate of alcoholics who continued misusing alcohol was much lower in DM (26%,P < 0.0005) and LC (35%, P < 0.0001) than in AL (73%).”

“The survival rate of those who stopped misusing alcohol was significantly higher in DM (90%, P < 0.0001), LC (88%, P < 0.0001) and AL (94%, P < 0.0005) than those who continued misusing alcohol.”

“As a result of these different actions, alcohol could result in either an increase or decrease in dexamethasone CL.”

“A reduction of hepatic peroxisome proliferation activator receptor-α (PPAR-α) was associated with coadministration of ethanol and dexamethasone.”

“Microarray and protein level analyses revealed two distinct changes … hepatic lipid metabolism in mice administered with both ethanol and dexamethasone : accelerated triglyceride synthesis by diacylglycerol O-acyltransferase 2 and suppressed fatty acid β-oxidation by long-chain acyl-CoA synthetase 1, carnitine palmitoyltransferase 1a, and acyl-CoA oxidase 1.”

“The effects of aldosterone and dexamethasone on (Na+K)-ATPase activity were augmented by ethanol in 50 and 19% of controls, respectively.”

“These results suggest that ethanol treatment enhances the upregulation of (Na+K)-ATPase activity by both aldosterone and dexamethasone , in cultured renal papillary collecting duct cells.”

“Treatment with a general inducing agent such as dexamethasone enhanced ethanol and 2-BE metabolism suggesting induction of multiple ADH isoforms.”

“Rats injected daily with dexamethasone and ethanol showed an antagonism to the acute effects of ethanol and a higher rate of tolerance development to the depressant effect of ethanol than animals administered ethanol only.”

“The rapid blockade of ethanol induced anxiolysis by dexamethasone strengthens the suggestion that a nongenomic mechanism may underlie this response.”

“Unilateral intrahippocampal injection of dexamethasone (2 and 20 nmol in 0.5 microl) also significantly attenuated the increased exploration of the open arms induced by ethanol.”