Possible Interaction: Ethanol and Desipramine

“In five out of six subjects, DMI significantly delayed both the absorption of alcohol (assessed by a breathalyser) and of paracetamol, and there was a correlation between the two.”

“The GIRK currents induced by ethanol were also attenuated in the presence of desipramine.”

“Conclusions: Desipramine treatment appeared to result in decreases in alcohol consumption in nonalcoholic patients with depression.”

“ Ethanol self-administration was also reduced 1 day after treatment with desipramine and fluoxetine but not with milnacipran.”

“Moreover, these effects of alcohol were blocked by pretreatment with desipramine , a tricyclic antidepressant, implicating a role for the biogenic amines in this type of depressive symptoms.”

“Daily treatment with desipramine (8 mg/kg) blocked all the changes induced by alcohol in both strains.”

“Results showed that desipramine , but not SERT-selective doses of citalopram or fluoxetine, strongly potentiated the depressant (not hypothermic) effects of ethanol.”

“ Desipramine , mianserin and alaproclate also increased ethanol plasma levels initially, but to a lesser extent.”

“In combination with desipramine, ethanol enhanced desipramine-induced decrease in beta-adrenoceptor density in the high-conformational state, but uncoupled beta-adrenoceptors, an effect not observed with ethanol alone.”

“However, ethanol in combination with chronic desipramine treatment prevented the reduction of beta-adrenoceptor density in frontal cortex produced by desipramine administration.”

“… ethanol … desipramine reduced the dissociation constant of the low affinity state of the receptor (KL) in frontal cortex from 23.1 +/- 3.7 microM in controls … desipramine produced a greater decrease in the percentage of cortical receptors in the high affinity state for agonist (%RH) than did desipramine alone.”