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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Ethanol
drug:
Deoxycholate
Research Papers that Mention the Interaction
“Class III alcohol dehydrogenase (chi chi-ADH) from human liver binds both ethanol and acetaldehyde so poorly that …, even at ethanol concentrations up to 3 M. However, long-chain carboxylates, e.g., pentanoate, octanoate, deoxycholate , and other … of ethanol and other substrates and hence … ADH up to 30-fold.”
Hydrophobic anion activation of human liver chi chi alcohol dehydrogenase.“The BA levels, especially the toxic BAs (chenodeoxycholic acid, deoxycholic acid and lithocholic acid), in the whole EHC were significantly increased by ethanol intake, which may provide a potential explanation to illuminate the pathogenesis of alcoholic liver injury.”
Chronic Alcohol Consumption Increased Bile Acid Levels in Enterohepatic Circulation and Reduced Efficacy of Irinotecan.“Experiments in vitro employing the everted-sac technique showed that the ethanol extract had the ability to inhibit taurocholate and deoxycholate absorption in a dose-dependent manner.”
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