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Last Updated: 5 years ago
supplement:
Ethanol
drug:
Deferoxamine
Research Papers that Mention the Interaction
“In HepG2 cells, desferrioxamine (Df), a potent iron chelator, abolished ferritin synthesis in the presence or absence of alcohol , and abolished the alcohol induction of ferritin mRNAs.”
“In rat hepatocytes, Df decreased ferritin synthesis to a similar level in the presence or absence of alcohol.”
Regulation of ferritin expression by alcohol in a human hepatoblastoma cell line and in rat hepatocyte cultures.“Deprivation of redox-active iron through desferrioxamine inhibits by about 50% the microsomal oxidation of ethanol in vitro and reduces very significantly in vivo the overall ethanol elimination rate in rats.”
“Signal intensity in the presence of desferrioxamine was about threefold higher after ethanol treatment.”
Increased NADPH- and NADH-dependent production of superoxide and hydroxyl radical by microsomes after chronic ethanol treatment.“In vivo, ethanol metabolism caused minimal breakage in hepatocyte DNA and addition of acetaldehyde (100 microM) markedly enhanced cleavage; all cleavage was inhibited by desferrioxamine.”
“ Desferrioxamine (5-10 microM) completely abolished alkane production induced by both ethanol and acetaldehyde, indicating the importance of catalytic iron.”
“ Desferrioxamine , an iron chelator and scavenger of superoxide radicals, administered prior to ethanol , prevents the changes in the cytosolic catalase activity, changes which are unaffected by the administration of allopurinol, an inhibitor of xanthine oxidase.”
“ Desferrioxamine , which completely blocks the production of .OH by microsomes, inhibited the oxidation of ethanol by about 60%, while the oxidation of 2-butanol and 1-butanol was decreased by only 30%.”
“… iron-chelating agent desferrioxamine , which blocks the generation of hydroxyl radicals in other systems, was found to inhibit the following microsomal reactions: production of formaldehyde from …-ol (t-butylalcohol); generation of ethylene from 4-oxothiomethylbutyric acid; release of 14CO2 from [I-14C]benzoate; production of acetaldehyde from ethanol or ….”
“Iron-EDTA, which increases the production of hydroxyl radicals, increased the NADPH-dependent oxidation of ethanol, whereas desferrioxamine , which blocks the production of hydroxyl radicals, inhibited the NADPH-dependent oxidation of ethanol.”
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