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Last Updated: 2 years ago

Possible Interaction: Ethanol and Deferoxamine

supplement:

Ethanol

Research Papers that Mention the Interaction

In HepG2 cells, desferrioxamine (Df), a potent iron chelator, abolished ferritin synthesis in the presence or absence of alcohol , and abolished the alcohol induction of ferritin mRNAs.
In rat hepatocytes, Df decreased ferritin synthesis to a similar level in the presence or absence of alcohol.
Journal of hepatology  •  1995  |  View Paper
Deprivation of redox-active iron through desferrioxamine inhibits by about 50% the microsomal oxidation of ethanol in vitro and reduces very significantly in vivo the overall ethanol elimination rate in rats.
Enzyme  •  1987  |  View Paper
Signal intensity in the presence of desferrioxamine was about threefold higher after ethanol treatment.
Archives of biochemistry and biophysics  •  1993  |  View Paper
In vivo, ethanol metabolism caused minimal breakage in hepatocyte DNA and addition of acetaldehyde (100 microM) markedly enhanced cleavage; all cleavage was inhibited by desferrioxamine.
Life sciences  •  1990  |  View Paper
Desferrioxamine (5-10 microM) completely abolished alkane production induced by both ethanol and acetaldehyde, indicating the importance of catalytic iron.
The Biochemical journal  •  1990  |  View Paper
Desferrioxamine , an iron chelator and scavenger of superoxide radicals, administered prior to ethanol , prevents the changes in the cytosolic catalase activity, changes which are unaffected by the administration of allopurinol, an inhibitor of xanthine oxidase.
Alcohol  •  1985  |  View Paper
Desferrioxamine , which completely blocks the production of .OH by microsomes, inhibited the oxidation of ethanol by about 60%, while the oxidation of 2-butanol and 1-butanol was decreased by only 30%.
Biochemistry  •  1984  |  View Paper
iron-chelating agent desferrioxamine , which blocks the generation of hydroxyl radicals in other systems, was found to inhibit the following microsomal reactions: production of formaldehyde from …-ol (t-butylalcohol); generation of ethylene from 4-oxothiomethylbutyric acid; release of 14CO2 from [I-14C]benzoate; production of acetaldehyde from ethanol or ….
The Biochemical journal  •  1983  |  View Paper
Iron-EDTA, which increases the production of hydroxyl radicals, increased the NADPH-dependent oxidation of ethanol, whereas desferrioxamine , which blocks the production of hydroxyl radicals, inhibited the NADPH-dependent oxidation of ethanol.
Archives of biochemistry and biophysics  •  1983  |  View Paper