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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Ethanol
drug:
Dantrolene
Research Papers that Mention the Interaction
“This effect of ethanol was apparently not due to an elevation of the intracellular free calcium but rather to a direct action … concentrations were tightly buffered with EGTA, (2) ethanol did not alter the efflux of 45Ca from the cells, and (3) dantrolene, … ethanol on intracellular calcium … of ethanol.”
Alcohol and the calcium-dependent potassium transport of human erythrocytes.“Our results showed that dantrolene selectively reduces ethanol-induced stimulation, loss of righting reflex, and ethanol intake in a dose dependent manner.”
Dantrolene blockade of ryanodine receptor impairs ethanol-induced behavioral stimulation, ethanol intake and loss of righting reflex“Incubation of rings with dantrolene (5 x 10(-5) mol/L), a ryanodine receptor blocker, or 2-aminoethyl diphenylborinate (7.5 x 10(-5) mol/L), an IP(3) receptor blocker, attenuated the vasodilating effect of alcohol on rings precontracted with PE.”
“In contrast, preincubation with 25 microM dantrolene , an inhibitor of Ca(2+) release from the sarcoplasmic reticulum, blocked the stimulation of 2-deoxyglucose uptake by ethanol.”
“The contraction induced by ethanol decreased on pretreatment with dantrolene as well as in Ca2+ free ringer.”
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