supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Ethanol
drug:
Dactinomycin
Research Papers that Mention the Interaction
“Cycloheximide and actinomycin D also inhibit the tolerance to morphine and ethanol in smooth muscle of rat vas deferens.”
Testosterone and tolerance in rat vas deferens.“ Actinomycin D (1.25 mg/kg, ip) prevented the increase in hepatic MT produced by ethanol , whereas inhibition of ethanol oxidation by pyrazole (150 mg/kg, ip) did not prevent the induction of hepatic MT.”
“However, the stimulation of hepatic ODC activity by ethanol was suppressed by actinomycin D or cycloheximide, indicating that the enhancement is attributable to the synthesis of new enzyme protein.”
“The subsequent enhancement of the enzyme activity by ethanol is not associated with stabilization of the enzyme, but is sensitive to actinomycin D and cycloheximide.”
“ Ethanol increased opioid receptor expression in NG108-15 cells treated with actinomycin D , but not cycloheximide; hence, normal protein synthesis, but not DNA transcription, may be required for this response.”
Ethanol increases the expression of functional delta-opioid receptors in neuroblastoma x glioma NG108-15 hybrid cells.
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback