Possible Interaction: Ethanol and Cysteine

“It was also demonstrated that the sulphydryl compounds β-mercaptoethylamine-HCl, cysteine and methionine significantly increased the survival rate of mice given a lethal dose of ethanol.”

“Dolai et al found that supraphysiologic concentration of CCK8 or a low concentration of CCK8 together with ethanol treatment increased cystein protease-mediated cleavage of STX2, which concurrently increased basolateral exocytosis and autophagy induction.”

“ Cysteines substituted at TM3 and TM4 sites previously suggested to interact with ethanol had less dramatic effects on ethanol inhibition.”

“The administration of L-cysteine , the precursor of H2S or NaHS, the exogenous donor of this gaseous molecule, significantly reduced gastric damage induced by ethanol , an agent that is known to induce acute gastric damage and hemorrhagic necrosis to the gastric mucosa.”

“CONCLUSIONS Et anol in take, but not diet, further enhances the changes in plasma aromatic amino acids, methionine and cys teine in duced by impaired liver function in patients with cirrhosis, suggesting a direct interference of alcohol in their metabolism.”

“Pretreatment with a selective iNOS inhibitor, L-N(6)-1-iminoethyl-lysine, or with antioxidants (ONOO(-) scavengers urate or L-cysteine ; superoxide anion scavenger superoxide dismutase) attenuated damage due to EtOH or to ONOO(-) generators.”

“ Ethanol exposure induced an increase in H2O2 and a decrease in GSH and Cys.”

“ Ethanol treatment reduced cysteine as well as glutathione levels in liver for 24 h. However, cysteine dioxygenase was up-regulated rapidly, and hypotaurine/taurine levels were significantly higher than those found in the saline-treated rats.”

“Intracellular antioxidants such as GSH and Cys are depleted following EtOH and Eh values increase.”

“In addition, the results indicate that reinstatement selectively activates ERK phosphorylation in the shell of the nucleus accumbens (Acb) and that pretreatment with L-cysteine reduces either reinstatement of EtOH seeking and reinstatement-elicited pERK in the AcbSh.”

“We previously observed that a nonessential amino acid, L-cysteine , significantly decreases oral ethanol (EtOH) self-administration, reinstatement of EtOH-drinking behavior, and EtOH self-administration break point.”