Possible Interaction: Ethanol and Cysteamine

“Preincubation of cells with PG, sucrose octasulfate, or the sulfhydryl compounds N-acetylcysteine, taurine, or cysteamine increased cell resistance </=21% against ethanol.”

“It significantly inhibited gastric ulceration induced by alcohol and aspirin, as well as cysteamine and histamine induced duodenal ulcers in rats and guinea pigs, respectively.”

“Irrespective of whether the animals were treated with 50% ethanol or not, the mucosal GSH levels were significantly decreased or increased, respectively, by DEM or cysteamine , and were not affected by both NEM and dmPGE2.”

“We …% ethanol induces striking damage to the microcirculation of glandular mucosa of the rat stomach with severe … sparing of capillary profiles near the muscularis mucosa, and pretreatment with the sulfhydryl agent, cysteamine , or with a large dose of prostaglandin F2 beta … abolish ethanol-induced damage to gastric mucosal capillaries.”

“Sulfhydryl compounds such as cysteine, reduced glutathione (GSH), and cysteamine prevented the lesion formation induced by acidified ethanol.”

“Intragastric administration of cysteamine or diethyl maleate caused a dose-dependent reduction in the mean area of gastric lesions induced by absolute ethanol but failed to affect gastric ulcerations produced by acidified aspirin.”

“The cytotoxicity of both ethanol and heat is enhanced by low pH and cysteamine ; it is reduced by deuterium oxide.”

“Treatment with beta-mercapto ethanol increases the portion of monomers.”